【摘要】：目的探討肝硬化腹水中鈣衛(wèi)蛋白水平對(duì)自發(fā)性細(xì)菌性腹膜炎(SBP)的診斷價(jià)值。方法從108例肝硬化腹水患者獲得136份腹水標(biāo)本,分成試驗(yàn)組(SBP)41份和對(duì)照組(非SBP)95份,檢測(cè)腹水中鈣衛(wèi)蛋白含量,同時(shí)兩組均收集臨床資料及腹水相關(guān)檢測(cè)結(jié)果,比較使用抗菌藥物前試驗(yàn)組和對(duì)照組腹水鈣衛(wèi)蛋白含量水平,以及試驗(yàn)組使用抗菌藥物前后腹水鈣衛(wèi)蛋白含量變化,繪制ROC曲線,確定腹水鈣衛(wèi)蛋白診斷SBP的臨界值。結(jié)果治療前試驗(yàn)組鈣衛(wèi)蛋白含量270~15 273ng/ml,顯著高于對(duì)照組0~75ng/ml(P0.001),試驗(yàn)組治療后鈣衛(wèi)蛋白含量9~13 043ng/ml,顯著低于治療前,差異有統(tǒng)計(jì)學(xué)意義(P0.01),鈣衛(wèi)蛋白與中性粒細(xì)胞(PMN)呈相關(guān)性(r=0.76039,P0.0001);以687ng/ml作為診斷的臨界值,此時(shí)鈣衛(wèi)蛋白診斷SBP的敏感性90.7%、特異性為86.3%。結(jié)論腹水中鈣衛(wèi)蛋白水平可以作為診斷SBP的特異性和敏感性較好的指標(biāo),值得臨床推廣。
[Abstract]:Objective to investigate the diagnostic value of calmodulin level in ascites of liver cirrhosis for spontaneous bacterial peritonitis (SBP). Methods one hundred and thirty-six ascites samples were collected from 108 patients with ascites of liver cirrhosis. They were divided into two groups: (SBP) group (n = 41) and control group (n = 95). The contents of Ca 2 + in ascites were measured. The clinical data and ascites related test results were collected in both groups. The levels of calcitonin in ascites of experimental group and control group were compared before and after the use of antimicrobial agents, and the changes of ascitic fluid calcitonin content in test group before and after the use of antimicrobial agents were compared. The ROC curve was plotted to determine the critical value of ascitic fluid calcitonin in diagnosis of SBP. Results before treatment, the calcitonin content in the trial group was significantly higher than that in the control group (P0.001), and that in the trial group was 9 ~ 13043 ng / ml, significantly lower than that in the control group before and after treatment, and the level of calcitonin in the experimental group was significantly lower than that in the control group (P0. 001). The difference was statistically significant (P0.01). There was a correlation between calcitonin and neutrophil (PMN) (r = 0.76039, P 0.0001), and when 687ng/ml was used as a critical value for diagnosis, the sensitivity and specificity of 687ng/ml in the diagnosis of SBP were 90.7 and 86.3 respectively. Conclusion the level of calmodulin in ascites can be used as a specific and sensitive index for the diagnosis of SBP, and it is worthy of clinical application.
【作者單位】： 湖北省新華醫(yī)院消化科;華中科技大學(xué)附屬同濟(jì)醫(yī)院感染科;
【基金】：湖北省自然科學(xué)基金資助項(xiàng)目(2011CDC104)
【分類(lèi)號(hào)】：R575.2

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本文編號(hào)：2200257