【摘要】：目的:分析丙型肝炎病毒(Hepatitis C virus,HCV)感染男性吸毒者血漿CCL19及CCL21濃度變化。方法:采用定量ELISA法檢測血漿CCL19和CCL21濃度,ELISA法檢測血漿抗HCV,Real-time RT-PCR法檢測HCV RNA,以國家哨點監(jiān)測HCV感染的391名男性吸毒者為研究對象,60名健康男性為對照,分析不同抗HCV/HCV RNA狀況男性吸毒者血漿CCL19和CCL21濃度變化。結(jié)果:391名男性吸毒者中,180名感染HCV,感染率為46.04%。未感染HCV男性吸毒組血漿CCL19及CCL21濃度較健康男性組升高(P≤0.001)。吸毒抗HCV(-)/HCV RNA(+)組血漿CCL19和CCL21濃度最低,與其他組差異明顯(P≤0.05);吸毒抗HCV(+)/HCV RNA(-)組的最高,與健康男性組差異顯著(P0.05)。結(jié)論:吸毒可使男性血漿CCL19和CCL21濃度升高。血漿CCL19和CCL21濃度升高可能有助于HCV自發(fā)清除;血漿CCL19和CCL21濃度降低可能預示著病程持續(xù)轉(zhuǎn)歸較差。
[Abstract]:Aim: to analyze the changes of plasma CCL19 and CCL21 levels in male drug users infected with hepatitis C virus (Hepatitis C virusus). Methods: plasma CCL19 and CCL21 concentration were detected by quantitative ELISA and Elisa respectively. HCV RNAs were detected by real-time RT-PCR assay and 60 healthy male drug users who were monitored for HCV infection by national sentinel. The changes of plasma CCL19 and CCL21 levels in male drug addicts with different anti-HCV/HCV RNA status were analyzed. Results among the 391 male drug users, 180 were infected with HCV, and the infection rate was 46.04. The concentrations of plasma CCL19 and CCL21 in the drug addicts group were higher than those in the healthy male group (P 鈮，

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