本文選題：清肝利膽膠囊 + 左氧氟沙星��； 參考：《中藥藥理與臨床》2017年01期

【摘要】：目的:觀察清肝利膽膠囊聯(lián)合左氧氟沙星治療肝膽濕熱型慢性膽囊炎的臨床療效。方法:納入2014年5月至2015年5月我院收治的中醫(yī)癥候?yàn)楦文憹駸嵝偷穆阅懩已谆颊?8例,按隨機(jī)數(shù)字表法分為觀察組49例和對照組49例。對照組給予左氧氟沙星治療,觀察組患者在對照組基礎(chǔ)上加用清肝利膽膠囊聯(lián)合治療。記錄并分析兩組患者治療前和治療后中醫(yī)癥候積分變化、腫瘤壞死因子(TNF-α)、β-內(nèi)啡呔(β-EP)、白細(xì)胞(WBC)、血清丙二醛(MDA)和血清超氧化歧化酶(SOD)水平的變化、膽囊B超療效和臨床療效。結(jié)果:觀察組治療后中醫(yī)癥狀積分為(6.73±2.07)分,顯著低于對照組(10.02±2.33)分。觀察組治療后TNF-α、β-EP和WBC水平分別為(0.8±0.1ng/ml、150.1±10.4pg/ml、7.11±0.36×109/L),均明顯低于對照組(1.1±0.1ng/ml、170.0±13.2pg/ml、8.14±0.47×109/L)。觀察組治療后MDA和SOD水平分別為(13.1±0.5nmol/ml、682.1±35.7ng/ml),均明顯優(yōu)于對照組(14.9±0.8nmol/ml、608.9±32.5ng/ml);4觀察組治療后膽囊B超療效總有效率為81.63%,顯著高于對照組59.18%。5觀察組治療后臨床療效總有效率為85.71%,顯著高于對照組61.22%。6治療后觀察組膽壁增厚、膽囊壁毛糙、膽囊體積變形和患者比例分別為(20.41%、22.45%、12.24%),均明顯低于對照組(42.86%、46.94%、30.61%)。結(jié)論:清肝利膽膠囊聯(lián)合左氧氟沙星可有效降低肝膽濕熱型慢性膽囊炎患者體內(nèi)炎癥水平,調(diào)節(jié)體內(nèi)相關(guān)因子水平,提高慢性膽囊炎的治療效果。
[Abstract]:Objective: to observe the clinical effect of Qinggan Lidan capsule combined with levofloxacin on chronic cholecystitis of damp-heat type of liver and gallbladder. Methods: from May 2014 to May 2015, 98 cases of chronic cholecystitis with the syndrome of dampness and heat of liver and gallbladder were included in our hospital. According to the method of random number table, they were divided into observation group (n = 49) and control group (n = 49). The patients in the control group were treated with levofloxacin and the patients in the observation group were treated with Qinggan Lidan capsule on the basis of the control group. The changes of TCM symptom score, tumor necrosis factor (TNF- 偽), 尾 -endorphin (尾 -EP), white blood cell (WBC), serum malondialdehyde (MDA) and serum superoxide dismutase (SOD) before and after treatment were recorded and analyzed. Results: the score of TCM symptom in the observation group was (6.73 鹵2.07), which was significantly lower than that in the control group (10.02 鹵2.33). After treatment, the levels of TNF- 偽, 尾 -EP and WBC in the observation group were (0.8 鹵0.1 ng / ml) 150.1 鹵10.4 PG / ml (7.11 鹵0.36 脳 10 9 / L), which were significantly lower than those in the control group (1.1 鹵0.1 ng / ml, 170.0 鹵13.2 PG / ml, 8.14 鹵0.47 脳 109 / L). After treatment, the levels of MDA and sod were (13.1 鹵0.5nmol / ml, 682.1 鹵35.7ng/ml) in the observation group, respectively, which were significantly superior to those in the control group (14.9 鹵0.8nmol / ml, 608.9 鹵32.5ng/ml). The total effective rate of B-ultrasound in the observation group was 81.630.It was significantly higher than that in the control group (59.18.5). The total effective rate was 85.71and significantly higher than that in the control group (85.71g). The gallbladder wall was thickened in the observation group after treatment with 61.22.6 in the control group. The gallbladder wall was rough, the volume deformation of gallbladder and the proportion of patients were 12.24%, respectively, which were significantly lower than those in the control group (42.86%, 46.94%). Conclusion: Qinggan Lidan capsule combined with levofloxacin can effectively reduce the level of inflammation in patients with chronic cholecystitis of damp-heat type of liver and gallbladder, regulate the level of related factors in the body and improve the therapeutic effect of chronic cholecystitis.
【作者單位】： 廣州中醫(yī)藥大學(xué);深圳市南山人民醫(yī)院;中國中醫(yī)科學(xué)院;
【分類號】：R575.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前7條

1 許彩紅;;膽舒膠囊聯(lián)合左氧氟沙星片治療慢性膽囊炎的臨床療效分析[J];海峽藥學(xué);2015年10期

2 張青;安加華;張成玉;;中西醫(yī)結(jié)合治療慢性膽囊炎45例[J];世界最新醫(yī)學(xué)信息文摘;2015年20期

3 黃衛(wèi)華;;消炎利膽止痛湯合左氧氟沙星治療慢性膽囊炎40例臨床觀察[J];中國民族民間醫(yī)藥;2015年08期

4 李日珍;;清肝利膽化濕法治療肝膽濕熱型慢性膽囊炎的臨床研究[J];中國衛(wèi)生產(chǎn)業(yè);2014年34期

5 王晶;;清肝利膽方治療肝膽濕熱型慢性膽囊炎76例療效觀察[J];中醫(yī)臨床研究;2014年01期

6 繆正亮;;中醫(yī)藥治療慢性膽囊炎186例體會[J];承德醫(yī)學(xué)院學(xué)報(bào);2011年03期

7 劉敏;趙亞偉;高星亮;;慢性膽囊炎中醫(yī)證候研究[J];中國中醫(yī)藥信息雜志;2010年04期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王彩鳳;;大柴胡湯聯(lián)合消炎利膽片治療肝膽濕熱型慢性膽囊炎的療效觀察[J];現(xiàn)代醫(yī)藥衛(wèi)生;2017年04期

2 廖茜s，

本文編號：2112446