本文選題：胰腺炎 + 脂籠蛋白質(zhì)類　； 參考：《中國(guó)普通外科雜志》2016年09期

【摘要】：目的:探討中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運(yùn)載蛋白(NGAL)及胃饑餓素(ghrelin)在急性胰腺炎(AP)患者外周血中水平高低與患者病情的關(guān)系。方法:收集既往收治的199例AP患者資料,其中急性輕癥胰腺炎(MAP)103例,急性重癥胰腺炎(SAP)96例;治療期間17例(8.54%)死亡,分別比較不同病情與不同治療轉(zhuǎn)歸及患者間入院第1天NGAL、ghrelin水平和其他指標(biāo)的差異。結(jié)果:SAP患者的NGAL、ghrelin、C反應(yīng)蛋白(CRP)、白細(xì)胞(WBC)、血淀粉酶、降鈣素原(PCT)、APACHE II評(píng)分、Balthazar CT評(píng)分、BISAP指數(shù)均明顯高于MAP組患者(均P0.05);治療期間死亡患者的以上指標(biāo)也均明顯高于存活患者(均P0.05);199例患者外周血中NGAL、ghrelin水平與BISAP指數(shù)呈明顯正相關(guān)關(guān)系(r=0.579、0.482,均P0.05),且兩者與BISAP指數(shù)的相關(guān)性優(yōu)于血淀粉酶、WBC、PCT。結(jié)論:AP患者外周血中NGAL、ghrelin水平與病情密切相關(guān),兩者水平增高預(yù)示著患者預(yù)后的不良的風(fēng)險(xiǎn)增大。
[Abstract]:Aim: to investigate the relationship between the levels of neutrophil gelatinase-associated lipid carrier protein (NGAL) and gastric hunger (ghrelin) in peripheral blood of patients with acute pancreatitis (AP). Methods: 199 cases of AP were collected, including 103 cases of mild acute pancreatitis (map) and 96 cases of severe acute pancreatitis (SAP), 17 cases (8.54%) died during the treatment. The difference of NGALL ghrelin level and other indexes were compared between patients with different disease and different treatment outcome and the first day of admission. Results the levels of C reactive protein (CRP), white blood cell (WBC), serum amylase and serum amylase were measured in patients with SAP. The BISAP index of Balthazar CT score was significantly higher than that of map group (P0.05), and the level of NGALA ghrelin and BISAP index in peripheral blood of 199 patients with PCT were significantly higher than those of surviving patients (P0.05). There was a positive correlation between BISAP index and BISAP index (P 0.05, P < 0.05), and the correlation between them was better than that of serum amylase WBCU PCT. Conclusion the level of NGALL ghrelin in the peripheral blood of the patients with 10% AP is closely related to the patient's condition, and the increase of the level of NGALL ghrelin may indicate the increased risk of poor prognosis in patients with AP.
【作者單位】： 天津醫(yī)科大學(xué)三中心臨床學(xué)院重癥醫(yī)學(xué)科;
【分類號(hào)】：R576
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本文編號(hào)：2073852