本文選題：降鈣素原 + 白介素　； 參考：《第二軍醫(yī)大學(xué)學(xué)報》2015年10期

【摘要】：目的分析降鈣素原(PCT)、白介素6(IL-6)、C-反應(yīng)蛋白(CRP)、中性粒細胞CD64、白細胞計數(shù)(WBC)、中性粒細胞比例等多種指標(biāo)聯(lián)合檢測診斷肝硬化患者合并感染的臨床價值。方法將肝硬化住院患者按照細菌培養(yǎng)結(jié)果和臨床癥狀分為感染組和非感染組,血清PCT、IL-6采用化學(xué)發(fā)光分析儀進行檢測,血清CRP采用生化分析儀進行檢測,中性粒細胞CD64采用流式細胞分析儀進行檢測,WBC和中性粒細胞比例采用全血細胞分析儀進行檢測。數(shù)據(jù)采用logistic回歸和受試者工作特征(ROC)曲線進行分析。結(jié)果感染組各項指標(biāo)均高于非感染組(P0.01)。Logistic回歸分析結(jié)果表明PCT、IL-6和中性粒細胞CD64具有預(yù)測肝硬化合并感染的能力,其OR值分別為7.199(95%CI:2.180~23.771)、1.010(95%CI:1.002~1.017)和2.312(95%CI:1.485~3.600);而CRP、WBC和中性粒細胞比例不具有預(yù)測價值。ROC曲線分析結(jié)果顯示,PCT、IL-6和中性粒細胞CD64的曲線下面積(AUC)分別為0.791(95%CI:0.727~0.856)、0.762(95%CI:0.693~0.832)和0.884(95%CI:0.835~0.933);三者聯(lián)合檢測的AUC為0.932(95%CI:0.897~0.967),診斷準確率為86.9%。結(jié)論PCT、IL-6和中性粒細胞CD64可以作為診斷肝硬化合并感染的指標(biāo),三者聯(lián)合檢測能夠提高臨床診斷效率。
[Abstract]:Objective to analyze the clinical value of combined detection of procalcitonin (PCT), interleukin-6 (IL-6) C-reactive protein (CRP), neutrophil CD64, white blood cell count (WBC) and neutrophil ratio in patients with cirrhosis. Methods the inpatients with liver cirrhosis were divided into infection group and non-infection group according to the bacterial culture results and clinical symptoms. The serum PCTX IL-6 was detected by chemiluminescence analyzer, and the serum CRP was detected by biochemical analyzer. Neutrophil CD64 was detected by flow cytometry and the ratio of neutrophil to neutrophil was detected by whole blood cell analyzer. The data were analyzed by logistic regression and operating characteristics (Roc) curves. Results all the indexes in infected group were higher than those in non-infected group (P0.01). Logistic regression analysis showed that PCTIL 6 and neutrophil CD64 had the ability to predict liver cirrhosis complicated with infection. 鍏禣R鍊煎垎鍒負7.199(95%CI:2.180~23.771),1.010(95%CI:1.002~1.017)鍜，

本文編號：2073123