本文選題：抗幽合劑 + 幽門螺桿菌��； 參考：《遼寧中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:觀察抗幽合劑聯(lián)合西藥四聯(lián)療法治療盤錦地區(qū)幽門螺桿菌陽性的慢性胃炎患者的幽門螺桿菌根除情況、癥狀改善以及中醫(yī)脾胃疾病患者報(bào)告臨床結(jié)局(PRO)量表[1]評分變化情況。方法:將符合納入標(biāo)準(zhǔn)的75例患者,采用隨機(jī)化方法,隨機(jī)分為三組,每組25例。其中A組予西藥四聯(lián)(奧美拉唑20mg、克拉霉素膠囊500mg、左氧氟沙星片200mg、枸櫞酸鉍鉀220mg)治療,BID,14天。B予西藥四聯(lián)治療+中藥辨證論治湯劑,BID,14天。C組予西藥四聯(lián)治療+抗幽合劑,BID,14天。入組當(dāng)天對所有患者進(jìn)行癥狀評分(附錄1)及PRO量表(附錄2)評分,安全評價(jià)(血尿便常規(guī),肝腎功能,心電圖)。入組2周后予停藥,進(jìn)行癥狀評分并記錄不良事件。停藥4周后復(fù)查14C尿素呼氣試驗(yàn),復(fù)查血尿便常規(guī),肝腎功能,心電圖,再次行PRO量表評分,記錄不良事件。用spss22.0統(tǒng)計(jì)軟件分析結(jié)果,觀察各組Hp根除率和癥狀改善情況以及中醫(yī)脾胃疾病患者報(bào)告臨床結(jié)局(PRO)量表評分變化情況。結(jié)果:1.A組(西藥組)Hp根除率72%,B組(西藥+中藥辨證)Hp根除率84%,C組(西藥+抗幽合劑)Hp根除率80%。2.C組治療后癥狀評分均較治療前明顯改善(P0.01),3.PRO量表評分中,C組與治療前比較消化不良、反流、排便、精神狀態(tài)、社會功能積分變化具有顯著差異(P0.01),總體狀態(tài)和健康滿意存在統(tǒng)計(jì)學(xué)差異(P0.05),C組在消化不良積分改善優(yōu)于B組(P0.05),C組在健康滿意積分改善優(yōu)于A組(P0.05)。結(jié)論:抗幽合劑聯(lián)合西藥四聯(lián),可以有效的提高慢性胃炎合并幽門螺桿菌陽性的患者幽門螺桿菌根除率,改善患者癥狀積分及PRO量表積分,并且在PRO量表中健康滿意項(xiàng)積分改善優(yōu)于單純西藥四聯(lián)療法,值得臨床進(jìn)一步研究和推廣。
[Abstract]:Objective: to observe the eradication of Helicobacter pylori in patients with chronic gastritis with positive Helicobacter pylori in Panjin area. Symptom improvement and the changes of clinical outcome (pro) scale [1] in patients with spleen and stomach diseases in TCM were reported. Methods: 75 patients who met the inclusion criteria were randomly divided into three groups, 25 cases in each group. Group A was given western medicine (omeprazole 20 mg, clarithromycin 500 mg, levofloxacin 200 mg, bismuth potassium citrate 220mg) for 14 days. B was given western medicine for 14 days. Symptom score (Appendix 1) and pro scale (Appendix 2), safety evaluation (hematuria routine, liver and kidney function, ECG) were performed on the same day. After 2 weeks, the drug was stopped, symptom score and adverse events were recorded. After 4 weeks of withdrawal, 14C urea breath test was reexamined, hematuria routine, liver and kidney function, electrocardiogram, pro scale score and adverse events were recorded again. The results of spss22.0 statistical software were used to observe the HP eradication rate and symptom improvement and the clinical outcome (pro) scale scores of the patients with spleen and stomach diseases in traditional Chinese medicine (TCM). Results 1. The eradication rate of HP in group A (western medicine group) and group B (differentiation of traditional Chinese medicine and western medicine) was significantly improved after treatment. The eradication rate of HP in group C (anti-you mixture for western medicine) was significantly improved compared with that before treatment (P0.01). The scores of reflux, defecation, mental state and social function were significantly different (P0.01). There was statistical difference between general state and health satisfaction (P0.05). The improvement of indigestion score in group C was better than that in group B (P0.05). The improvement of score of health satisfaction in group C was better than that in group A (P0.05). Conclusion: the combination of Kangyou mixture and western medicine can effectively improve the eradication rate of Helicobacter pylori in patients with chronic gastritis and Helicobacter pylori positive patients, and improve the symptom score and pro scale score of patients with chronic gastritis and Helicobacter pylori positive patients. The improvement of the score of health satisfaction item in pro scale is better than that of western medicine combined therapy alone, which is worthy of further clinical study and popularization.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R573.3
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本文編號：2072966