本文選題：肝硬化 + 雙歧桿菌三聯(lián)活菌膠囊�。� 參考：《中國(guó)藥房》2016年05期

【摘要】：目的:探討雙歧桿菌三聯(lián)活菌膠囊聯(lián)合大黃赤芍湯對(duì)肝硬化患者內(nèi)毒素血癥及腸黏膜屏障功能的影響。方法:90例肝硬化患者按照隨機(jī)數(shù)字表法分為中西醫(yī)組和西醫(yī)組,各45例。兩組患者均予以保肝利尿、降低門脈壓和營(yíng)養(yǎng)支持等對(duì)癥治療。在此基礎(chǔ)上,西醫(yī)組患者予以雙歧桿菌三聯(lián)活菌膠囊0.42 g,tid,po;中西醫(yī)組患者在西醫(yī)組治療基礎(chǔ)上加用大黃赤芍湯口服,每天1劑,兩組均連用6周。觀察并記錄兩組患者治療前后肝功能指標(biāo)與血清內(nèi)毒素(ET)、降鈣素原(PCT)和二胺氧化酶(DAO)水平。結(jié)果:治療6周后,兩組患者血清丙氨酸轉(zhuǎn)氨酶(ALT)、天冬氨酸轉(zhuǎn)氨酶(AST)、總膽紅素(TBIL)、ET、PCT和DAO水平均較治療前明顯下降,差異有統(tǒng)計(jì)學(xué)意義(P0.05或P0.01),且中西醫(yī)組下降幅度明顯大于西醫(yī)組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:雙歧桿菌三聯(lián)活菌膠囊聯(lián)合大黃赤芍湯治療肝硬化患者,能降低血清ALT、AST和TBIL水平,保護(hù)患者肝功能;還能降低血清ET、PCT和DAO水平,減輕內(nèi)毒素血癥,保護(hù)與修復(fù)腸黏膜屏障功能。
[Abstract]:Aim: to investigate the effects of Bifidobacterium triple active bacilli capsule combined with rhubarb red paeoniae decoction on endotoxemia and intestinal mucosal barrier function in patients with liver cirrhosis. Methods 90 patients with liver cirrhosis were randomly divided into traditional Chinese and western medicine group. Both groups were treated with liver-diuretic, portal pulse pressure reduction and nutritional support. On this basis, the patients in the western medicine group were given bifidobacterium triple biotic capsule 0.42 g tidtidpropo.On the basis of western medicine group, the patients in the traditional Chinese and western medicine group were treated with rhubarb red paeoniae decoction orally, once a day, both groups were used continuously for 6 weeks. Liver function and serum endotoxin (et), procalcitonin (PCT) and diamine oxidase (Dao) levels were observed and recorded before and after treatment. Results: after 6 weeks of treatment, the levels of alt, AST, TBIL ETP PCT and Dao in the two groups were significantly lower than those before treatment (P0.05 or P0.01), and the decrease of serum alt, AST, TBIL and Dao in the two groups was significantly higher than that in the western medicine group (P0.05 or P0.01), and the decrease of serum alt, AST, TBIL in the two groups was significantly higher than that in the western medicine group (P0.05 or P0.01). The difference was statistically significant (P0.05). Conclusion: Bifidobacterium triple viable capsule combined with rhubarb and red paeoniae decoction can reduce serum alt and TBIL levels, protect liver function, decrease serum ETT and Dao levels and alleviate endotoxemia. Protect and repair intestinal mucosal barrier function.
【作者單位】： 浙江省遂昌縣中醫(yī)院中西醫(yī)結(jié)合內(nèi)科;浙江省遂昌縣中醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R575.2

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