本文選題：MRI對比劑 + 胰腺圖像��； 參考：《吉林大學》2014年碩士論文

【摘要】：目的：為提高病胰腺病變的檢出率與確診率，我們引入了對比劑，，以便增強正常組織與病變組織與的信號強度差。選擇合適的對比劑，就會避免注射對比劑后患者產(chǎn)生一些不良反應(yīng)。本研究對MRI對比劑的注射速率、濃度進行量化分析，對對比劑所產(chǎn)生的副反應(yīng)進行詳細觀察，獲得了比較合適的對比劑選擇和注射方案。 材料與方法：選取胰腺MRI增強掃描的患者120例，排除其他疾病情況下的患者。選取腹主動脈、3處正常胰腺實質(zhì)作為感興趣區(qū)，分別測已選取的固定5處的信號強度，評價各組間腹主動脈，3處胰腺實質(zhì)的信號強度，比較應(yīng)用不同注射速率、不同濃度對比劑進行MRI增強掃描時圖像質(zhì)量的差異。 結(jié)果：濃度0.08mmol/kg，0.06mmol/kg的對比劑較濃度0.02mmol/kg的對比劑可以獲得更佳的MRI圖像，對比劑濃度的高低對患者產(chǎn)生的副反應(yīng)并無明顯差別。對比劑的注射速率2ml/s與注射速率3ml/s對胰腺MRI圖像的成像質(zhì)量無顯著的影響，而注射速率3ml/s組較注射速率2ml/s組的患者引起的副反應(yīng)發(fā)生率高。本次研究選取的120例患者行MRI檢查前48h內(nèi)檢查肌酐（Cr）、尿素氮（BUN），檢查后血漿Cr、BUN無升高。注射對比劑前后體征，包括：血壓、脈搏、體溫、無明顯差異。本次研究選取的120例患者注射對比劑后有15例出現(xiàn)注射部位局部不同程度疼痛、腫脹，其中注射速率2ml/s的患者有4例，注射速率3ml/s的患者有11例。 結(jié)論：本實驗對120例胰腺增強MRI檢查患者的圖像成像質(zhì)量及對比劑產(chǎn)生的副反應(yīng)進行分析，得出注射速率2ml/s，濃度0.08mmol/kg，0.06mmol/kg的對比劑在獲得較好的MRI圖像的同時減少了患者的副反應(yīng)，成為本次研究得出的一組在胰腺成像中效價比高的對比劑使用參數(shù)。
[Abstract]:Objective: in order to improve the detection rate and diagnosis rate of pancreatic disease, we introduced contrast agent to enhance the signal intensity difference between normal tissue and pathological tissue. Choose the appropriate contrast agent, you will avoid some adverse reactions after injection of contrast agent. In this study, the injection rate and concentration of MRI contrast agent were analyzed quantitatively, the side effects of contrast agent were observed in detail, and the suitable contrast agent selection and injection scheme were obtained. Materials and methods: 120 patients with enhanced MRI were selected to exclude other diseases. Three normal pancreatic parenchyma of abdominal aorta were selected as regions of interest. The signal intensities of 5 fixed sites were measured to evaluate the signal intensity of pancreatic parenchyma at 3 sites of abdominal aorta, and different injection rates were compared. The difference in image quality of MRI enhanced scanning with different concentrations of contrast agent. Results: 0.08 mmol 路kg ~ (-1) 路kg ~ (-1) concentration of 0.06 mmol 路kg ~ (-1) contrast agent could obtain better 0.02mmol/kg images than that of 0.02mmol/kg, and there was no significant difference in the side effects of the concentration of contrast agent. Contrast medium injection rate (2ml/s) and injection rate (3ml/s) had no significant effect on the imaging quality of pancreatic MRI, but the incidence of side effects in the injection rate 3ml/s group was higher than that in the injection rate 2ml/s group. In this study, 120 patients were examined for creatinine bun and bun within 48 hours before MRI. Signs before and after injection, including: blood pressure, pulse, body temperature, there was no significant difference. There were 15 patients with local pain and swelling at the injection site after injection of contrast agent. Four patients with injection rate 2ml/s and 11 patients with injection rate 3ml/s were involved in this study. Conclusion: the imaging quality of 120 patients with enhanced MRI and the side effects of contrast media were analyzed. The results showed that the injection rate of 2 ml / s and the concentration of 0.08 mmol / kg 0.06 mmol / kg decreased the side effects of MRI images. As a result of this study, a group of high titer in pancreatic imaging contrast agent use parameters.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R576;R445.2

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