本文選題：肝硬化 + 生存質(zhì)量　； 參考：《山西醫(yī)科大學(xué)》2014年碩士論文

【摘要】：研究目的： 本研究的目的是了解由三種不同原因所導(dǎo)致的肝硬化患者生存質(zhì)量的狀況和差異,并就可能影響其生存質(zhì)量的主要因素進(jìn)行探討,了解患者的需求和需要幫助的程度,為肝硬化患者改善和提高其生存質(zhì)量給予相應(yīng)的理論基礎(chǔ)的提供。 研究方法： 采用方便抽樣原則,應(yīng)用簡明生命質(zhì)量測量量表(SF-36)中文版對試驗(yàn)組肝硬化患者120例[根據(jù)病因不同分為肝炎肝硬化(60例)、酒精性肝硬化(30例)、原發(fā)性膽汁性肝硬化(30例)3組]和對照組健康人群(30例)進(jìn)行調(diào)查。比較各組間生存質(zhì)量總分及8個(gè)維度(軀體健康、軀體角色功能、軀體疼痛、總體健康感受、精力、社會(huì)功能、情緒角色功能和心理健康)的得分,進(jìn)一步探討肝硬化患者生存質(zhì)量的狀況。同時(shí)收集各研究對象組的一般特征,試驗(yàn)組同時(shí)收集可能與肝硬化患者生存質(zhì)量相關(guān)的因素,包括疾病相關(guān)因素和非疾病相關(guān)因素兩部分內(nèi)容,應(yīng)用SPSS10.0統(tǒng)計(jì)軟件包進(jìn)行數(shù)據(jù)處理,采用相關(guān)統(tǒng)計(jì)描述,并采用秩和檢驗(yàn)、方差分析和多元回歸等統(tǒng)計(jì)方法進(jìn)行分析,研究與肝硬化患者生存質(zhì)量相關(guān)的主要因素。 研究結(jié)果： 1.三組不同病因的肝硬化患者的生存質(zhì)量與正常人群相比均有不同程度降低。在總體生存質(zhì)量及除軀體疼痛外的7個(gè)維度上肝硬化患者組均比正常對照組降低。3組不同病因的肝硬化患者的生存質(zhì)量進(jìn)行組間比較,酒精性硬肝化患者組在生存質(zhì)量總分及軀體角色功能、社會(huì)功能、情緒角色功能、心理健康4個(gè)維度上均比肝炎肝硬化患者組和原發(fā)性膽汁性肝硬化降低,而肝炎肝硬化患者組和原發(fā)性膽汁性肝硬化患者組相比,則在情緒角色功能1個(gè)維度降低。 2.在其他條件相同的情況下,患者的肝硬化Child-pugh分級(jí)、發(fā)病時(shí)間、自覺不適癥狀與患者的生存質(zhì)量呈負(fù)相關(guān)；患者的社會(huì)支持程度越高,醫(yī)保狀況越完善、焦慮、抑郁程度越低,年齡越大,患者的生存質(zhì)量就越高,除酒精性肝硬化的患者外,男性較女性的生存質(zhì)量高。而患者的家庭人均收入、教育水平、營養(yǎng)狀況則與生存質(zhì)量無明顯相關(guān)性。 結(jié)論 肝硬化患者的生存質(zhì)量明顯下降,包括年齡、病程、Child-pugh分級(jí)、不適癥狀、焦慮與抑郁程度、性別、醫(yī)療費(fèi)用支付方式、社會(huì)支持在內(nèi)的諸多因素皆影響肝硬化患者的生存質(zhì)量。
[Abstract]:Objective: the purpose of this study was to understand the status and difference of quality of life in patients with cirrhosis caused by three different causes, and to explore the main factors that may affect their quality of life. To understand the needs of patients and the degree of need for help to provide a theoretical basis for improving and improving the quality of life of patients with liver cirrhosis. Research methods: using the principle of convenient sampling, A brief quality of life scale (SF-36) was used in 120 patients with liver cirrhosis in the trial group (60 cases of hepatitis cirrhosis, 30 cases of alcoholic cirrhosis and 30 cases of primary biliary cirrhosis) according to their etiology. Group A (30 cases of healthy population) were investigated. The scores of total scores of quality of life and 8 dimensions (physical health, physical role function, physical pain, overall health feeling, energy, social function, emotional role function and mental health) were compared between the groups. To further investigate the quality of life in patients with cirrhosis. At the same time, the general characteristics of the study groups were collected, and the factors that might be related to the quality of life of patients with liver cirrhosis, including disease-related factors and non-disease-related factors, were collected simultaneously in the trial group. The data were processed by SPSS 10.0 software package, and the correlation statistical description was used. The main factors related to the quality of life of patients with liver cirrhosis were analyzed by rank sum test, variance analysis and multivariate regression. Results: 1. The quality of life of three groups of cirrhosis patients with different etiology was lower than that of normal people. The overall quality of life (QOL) and the quality of life (QOL) of cirrhotic patients with different etiology were lower than those of the normal control group in 7 dimensions except somatic pain. The total quality of life (QOL) scores, somatic role function, social function, emotional role function and mental health in alcoholic group were lower than those in patients with hepatitis cirrhosis and primary biliary cirrhosis. Compared with patients with primary biliary cirrhosis, there was a decrease of 1 dimension of emotional role function in patients with hepatitis and cirrhosis. 2. 2. Under the same conditions, Child-pugh grade, onset time, symptoms of discomfort were negatively correlated with the patients' quality of life; the higher the social support, the better the health insurance, the lower the anxiety, the lower the depression. The older the patient, the higher the quality of life, with the exception of alcoholic cirrhosis, higher quality of life for men than for women. There was no significant correlation between family income, education, nutrition and quality of life. Conclusion the quality of life of patients with liver cirrhosis decreased significantly, including age, course of disease, Child-pugh grade, symptoms of discomfort, anxiety and depression, sex, and the way of paying for medical expenses. Many factors, including social support, affect the quality of life of patients with liver cirrhosis.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R575.2

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