發(fā)布時間：2018-06-15 23:06

  本文選題：正五聚蛋白 + 急性胰腺炎　； 參考：《山東醫(yī)藥》2016年22期

【摘要】：目的探討急性胰腺炎(AP)患者血漿正五聚蛋白3(PTX-3)水平與早期炎癥反應及嚴重程度的關系。方法選擇AP患者62例,其中輕度32例(MAP組)、中度18例(MSAP組)、重度12例(SAP組)。另擇同期健康體檢者25例作為對照組。檢測血漿PTX3及炎性因子IL-6、IL-8、TNF-α,采用APACHEⅡ評分、Ranson評分評估病情嚴重程度,Pearson相關分析血漿PTX3與炎性因子、APACHEⅡ評分、Ranson評分的相關性。結果 AP患者入院時血漿PTX3均高于對照組;以SAP組最高,MSAP組次之,MAP組最低(P均0.01)。SAP組血漿IL-6、IL-8、TNF-α及APACHEⅡ評分、Ranson評分均高于MSAP組和MAP組,MSAP組高于MAP組(P均0.01)。血漿PTX3與IL-6、IL-8、TNF-α及APACHEⅡ評分、Ranson評分均呈顯著正相關(r分別為0.726、0.908、0.899、0.780、0.620,P均0.05)。結論血漿PTX3在AP患者早期炎癥程度、病情嚴重程度評估方面具有一定的應用價值,有可能成為SAP早期診斷和預后判斷的指標之一。
[Abstract]:Objective to investigate the relationship between plasma normal pentagglutinin 3 (PTX-3) level and early inflammatory reaction in patients with acute pancreatitis (AP). Methods 62 cases of AP were selected, including 32 cases of mild map group, 18 cases of moderate MSAP group and 12 cases of severe SAP group. Another 25 healthy persons were selected as control group. Plasma PTX3 and IL-6 IL-8 TNF- 偽 were detected. The correlation between plasma PTX3 and inflammatory factor Apache 鈪，

本文編號：2024024