本文選題：肝體積 + 全肝灌注成像��； 參考：《南京醫(yī)科大學(xué)學(xué)報(自然科學(xué)版)》2015年03期

【摘要】：目的 :探討全肝灌注+肝臟體積一站式檢查評價肝硬化患者肝臟儲備功能的應(yīng)用價值。方法 :肝功能正常組20例及肝硬化組23例均行256層CT全肝灌注和常規(guī)上腹部增強(qiáng)掃描,將灌注數(shù)據(jù)和增強(qiáng)門脈期薄層數(shù)據(jù)分別經(jīng)Functional軟件及肝段分析處理后,得出全肝灌注參數(shù)值和體積值,取各段灌注參數(shù)平均值作為全肝灌注參數(shù)值。對肝硬化組應(yīng)用Child-pugh(C-P)分級進(jìn)行分組,比較肝功能正常組與Child A、B、C各組間肝臟體積、全肝灌注參數(shù)的差異;并計算得出綜合指標(biāo),分別與肝功能C-P分級分?jǐn)?shù)進(jìn)行相關(guān)性分析。結(jié)果:隨著肝功能受損程度的加重,肝動脈灌注量(hepatic arterial perfusion,HAP)、肝動脈灌注指數(shù)(hepatic arterial perfusion index,HAPI)呈逐級上升,門靜脈灌注量(hepatic portal perfusion,HPP)、肝總灌注量(total liver perfusion,TLP)、門靜脈灌注指數(shù)(hepatic portal perfusion index,HPPI)呈逐級遞減,相關(guān)性系數(shù)分別為:rHAP=0.382,rHAPI=0.841,rHPP=-0.761,rTLP=-0.594,rHPPI=-0.846;肝臟體積(liver volume,LV)、單位體表面積肝臟體積(liver volume per body surface area,LVs)呈逐級遞減,rLV=-0.875,rLVs=-0.933;單位體表面積肝臟體積-門靜脈灌注指數(shù)(volume hepatic portal perfusion index per body surface area,VHPPILs)呈逐級遞減,rVHPPILs=-0.945。結(jié)論 :肝血流灌注及肝體積的改變與肝硬化臨床分級相關(guān),VHPPILs綜合指標(biāo)更全面地詮釋了肝臟儲備功能,可用于定量評估肝硬化患者肝臟整體儲備功能。
[Abstract]:Objective: to evaluate the value of one-stop liver perfusion volume test in evaluating liver reserve function in patients with liver cirrhosis. Methods: 20 cases of normal liver function group and 23 cases of liver cirrhosis group underwent 256-slice CT whole liver perfusion and routine upper abdominal enhanced scanning. The perfusion data and enhanced portal phase thin layer data were analyzed by functional software and hepatic segment analysis, respectively. The whole liver perfusion parameters and volume values were obtained, and the average perfusion parameters were taken as the whole liver perfusion parameters. The liver volume and perfusion parameters were compared between normal liver function group and Child Afib C group, and the comprehensive indexes were calculated, and the correlation between liver function C-P score and liver function C-P score was analyzed. Results: with the severity of liver function damage, hepatic arterial perfusion volume and hepatic artery perfusion index (HAPI) increased step by step, and portal vein perfusion volume was increased gradually, total liver perfusion volume was increased, total liver perfusion volume and hepatic portal perfusion index (HPPI) were decreased step by step, respectively, and hepatic arterial perfusion index (HAPI) was decreased gradually, and hepatic arterial perfusion index (HAPI) was decreased gradually with hepatic arterial perfusion (HAPI), hepatic portal perfusion index (HAPI), total liver perfusion volume (TLP), hepatic artery perfusion index (HAPI) and hepatic perfusion index (HAPI). The correlation coefficients were 0.841 ~ 0. 761 ~ 0. 761 ~ 0. 761 ~ 0. 594 ~ 0. 594 ~ 0. 594 ~ 0. 594 ~ 0. 846 rHPPIP ~ 0. 846, respectively. The volume of liver volume and volume of volume per body surface were decreased gradually, rLV- 0. 875 ~ 0. 875 ~ 0. 933 and rVHPPILs / volume / volume of portal vein perfusion / volume / portal vein perfusion index / volume / portal vein perfusion index (hepatic portal perfusion index per body surface / VHPPILs) were gradually decreased respectively (r LVL = 0. 382%) and rVHPPILs (r = 0. 875%) and rVHPPILs (n = 0. 945) respectively. The correlation coefficients were 0. 842% (n = 10) and 0. 841% (n = 10), respectively. Conclusion: the changes of hepatic blood flow perfusion and liver volume are related to the clinical grade of liver cirrhosis. The comprehensive indexes of VHPPILs can be used to quantitatively evaluate the liver reserve function in patients with liver cirrhosis.
【作者單位】： 南通大學(xué)第三附屬醫(yī)院放射科;河北省邯鄲市中心醫(yī)院CT室;
【基金】：無錫市醫(yī)院管理中心醫(yī)學(xué)技術(shù)重大項目(YGZF1108)
【分類號】：R575.2

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