本文選題：脂肪肝 + 非酒精性��； 參考：《實(shí)用醫(yī)學(xué)雜志》2015年09期

【摘要】：目的:探討青島地區(qū)漢族人群脂聯(lián)素(ADIPOQ)基因rs266729和rs2241766兩位點(diǎn)的多態(tài)性與非酒精性脂肪性肝病(NAFLD)的相關(guān)性。方法:采用多聚酶鏈反應(yīng)(PCR)及基因型檢測(cè)的方法對(duì)青島地區(qū)漢族人群338例NAFLD患者(NAFLD組)和280例正常人群(對(duì)照組)進(jìn)行基因型的檢測(cè),采用Pearsonχ2檢驗(yàn)、Logistic回歸分析、t檢驗(yàn)等方法對(duì)各組基因型、等位基因以及臨床資料進(jìn)行比較。結(jié)果:脂聯(lián)素rs266729位點(diǎn)基因型及等位基因頻率在NAFLD組與對(duì)照組之間存在明顯差異(χ2=9.929,P=0.007;χ2=9.809,P=0.002)。校正混雜因素后,G等位基因攜帶者患NAFLD的風(fēng)險(xiǎn)是C等位基因的1.41倍(OR=1.410,95%CI:1.082~1.831,P=0.008)。而rs2241766基因型及等位基因在兩組中未見(jiàn)明顯差異(χ2=0.327,P=0.849;χ2=0.074,P=0.785)。結(jié)論 :在青島地區(qū)漢族人群中,脂聯(lián)素基因rs266729G等位基因攜帶者罹患NAFLD的風(fēng)險(xiǎn)增加,而rs2241766基因多態(tài)性與NAFLD的發(fā)病無(wú)明顯相關(guān)性。
[Abstract]:Objective: to investigate the relationship between the polymorphism of adiponectin (ADIPOQ) gene rs266729 and rs2241766 and NAF LDD in Qingdao Han population. Methods: the genotypes of 338 NAFLD patients and 280 normal controls were detected by polymerase chain reaction (PCR) and genotypic detection. The genotypes, alleles and clinical data of each group were compared by Pearson 蠂 2 test and logistic regression analysis. Results: the genotypes and allelic frequencies of adiponectin rs266729 locus were significantly different between NAFLD group and control group (蠂 2 9. 929 P 0. 007; 蠂 2 9. 809 P 0. 002). After adjusting for confounding factors, the risk of NAFLD in G allele carriers was 1.41 times higher than that in C alleles. The risk of NAFLD was 1.41 times higher than that of C alleles. The risk of NAFLD was 1.41 times higher than that of C alleles. However, there was no significant difference in genotype and allele of rs2241766 between the two groups (蠂 2, 0.327, P < 0. 849; 蠂 2, 0. 074, P < 0. 785). Conclusion: the allele carriers of adiponectin gene rs266729G have an increased risk of NAFLD in Qingdao Han population, but the polymorphism of rs2241766 gene has no significant correlation with the occurrence of NAFLD.
【作者單位】： 南京醫(yī)科大學(xué)青島臨床醫(yī)學(xué)院;山東省青島市市立醫(yī)院消化內(nèi)二科;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(編號(hào):81170337) 青島市民生科技計(jì)劃項(xiàng)目(編號(hào):14-2-3-17-nsh)
【分類號(hào)】：R575.5

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