本文選題：自體骨髓干細(xì)胞移植 + 肝硬化　； 參考：《中國老年學(xué)雜志》2017年22期

【摘要】：目的探討自體骨髓干細(xì)胞(BMSCs)移植技術(shù)對(duì)肝硬化的臨床療效。方法計(jì)算機(jī)檢索中國知網(wǎng)、萬方、重慶維普、Pub Med、Cochrance Library五大數(shù)據(jù)庫,由兩名研究者分別納入符合標(biāo)準(zhǔn)的自體骨髓干細(xì)胞治療肝硬化的隨機(jī)對(duì)照試驗(yàn)(RCT)試驗(yàn),提取資料并進(jìn)行方法學(xué)評(píng)級(jí),采用Rev Man5.3軟件進(jìn)行meta分析。結(jié)果共納入10個(gè)隨機(jī)對(duì)照試驗(yàn)(RCT)試驗(yàn),566例患者。系統(tǒng)評(píng)價(jià)結(jié)果結(jié)果顯示:ALB、TBIL、PT、PTA均有明顯改善,臨床癥狀均明顯減輕(P0.05)。結(jié)論自體BMSCs移植治療肝硬化是有效的,但仍需要基礎(chǔ)研究和大樣本的隨機(jī)對(duì)照試驗(yàn)。
[Abstract]:Objective to investigate the clinical effect of autologous bone marrow stem cell transplantation (BMSCs) on liver cirrhosis. Methods five databases of China Zhiwang, Wanfang and Chongqing Weipu Pub MedCochrance Library were searched. The two researchers were included in the randomized controlled trial of autologous bone marrow stem cells for the treatment of liver cirrhosis. The data were extracted and the methodology was rated. Meta analysis was carried out with Rev Man5.3 software. Results A total of 566 patients were enrolled in 10 randomized controlled trials (RCTs). The results of systematic evaluation showed that the PTPTA of TBILP were significantly improved and the clinical symptoms were significantly alleviated (P0.05). Conclusion autologous BMSCs transplantation is effective in the treatment of liver cirrhosis, but it still needs basic research and large sample randomized controlled trial.
【作者單位】： 新疆醫(yī)科大學(xué)第五附屬醫(yī)院胃腸外科;新疆醫(yī)科大學(xué)第五附屬醫(yī)院血管腫瘤介入科;
【分類號(hào)】：R575.2

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