本文選題：食管pH膠囊(OMOM) + 胃食管反流病��； 參考：《福建醫(yī)科大學(xué)》2014年碩士論文

【摘要】：第一部分 食管pH膠囊對胃食管反流病的診斷價值研究 目的：探討國產(chǎn)食管pH膠囊在胃食管反流病中的的診斷價值。 方法：選取臨床診斷為胃食管反流�。℅ERD）的28例患者進行導(dǎo)管式24h食管pH監(jiān)測檢查，間隔1天后進行食管pH膠囊監(jiān)測檢查，pH膠囊及pH導(dǎo)管探頭均放置于胃食管交界處以上6cm處，比較患者對兩種方法的耐受情況，并分析比較兩者數(shù)據(jù)之間的差異性。 結(jié)果：28例GERD患者均完成了兩種檢測方法，4例患者因食管pH膠囊本身技術(shù)故障，另2例患者因pH膠囊過早脫落，導(dǎo)致檢測時間未達到48h，，以上6例的食管pH監(jiān)測數(shù)據(jù)均被排除。剩余22例患者順利的完成了48h的食管pH膠囊監(jiān)測�；颊邔κ彻躳H膠囊的耐受性良好。并對比分析兩種檢測方法的數(shù)據(jù)，得出食管pH膠囊對GERD的診斷敏感性為93.33%，特異性為85.71%，準確性為90.91%。與導(dǎo)管式食管pH監(jiān)測比較，食管pH膠囊組的總的pH＜4的百分時間（8.5%），直立位pH＜4的時間（10.4%），總的反流次數(shù)（42.6次）均顯著高于導(dǎo)管組（分別為6.4%，6.2%，26.4次），各指標比較有統(tǒng)計學(xué)差異（P均0.05）。且食管pH膠囊組和導(dǎo)管式pH監(jiān)測組關(guān)于食管酸反流方面的相關(guān)性比較，亦有顯著的相關(guān)性（r=0.87，P0.0001）。食管pH膠囊組第二天的pH值4占總時間的百分比（8.5），pH值4的直立位時間百分比（12.5），平均長反流的次數(shù)（26.4）均顯著高于第一天的，各指標比較有統(tǒng)計學(xué)意義（P0.05） 結(jié)論：與導(dǎo)管式24h食管pH監(jiān)測方法比較，國產(chǎn)食管pH膠囊檢測方法的有效性高、耐受性好，食管pH膠囊是適合用于診斷胃食管反流病的食管內(nèi)酸反流的理想檢查工具。 第二部分 同步進行導(dǎo)管式24小時食管pH監(jiān)測與食管pH膠囊監(jiān)測的一致性的臨床研究 目的： 探討同步進行導(dǎo)管式24小時食管pH監(jiān)測系統(tǒng)與食管pH膠囊監(jiān)測系統(tǒng)檢測GERD患者食管酸反流的相關(guān)性及一致性。 方法： 24例擬診為GERD的患者，同時將導(dǎo)管式24h食管pH監(jiān)測的導(dǎo)管前端的電極與國產(chǎn)食管pH膠囊的電極置于食管下括約肌上方5cm處，分別應(yīng)用對應(yīng)的接收器接收數(shù)據(jù)，分別記錄24小時及48小時的食管pH數(shù)據(jù)，并進行比較，研究其相關(guān)性和一致性，期間記錄患者不適癥狀。 結(jié)果： 在第一天，食管pH膠囊組檢測到pH4占總時間的%數(shù)值比導(dǎo)管式24h食管pH監(jiān)測組更低（5.8%VS.6.8%，p＜0.05）；兩組檢測的結(jié)果存在顯著的相關(guān)性（r=0.90，P0.0001）。兩種檢測方法診斷GERD的一致性為86.4%。食管pH膠囊組中，檢測48h與第一天相比，對食管酸反流各指標間的結(jié)果均有顯著性差異（P0.05）；而48h與第二天比較，在總的、直立位時pH4所占的時間百分比有顯著性差異（P0.05）。同樣，對比了患者對這2種方法的主觀感覺，大部分患者訴在第一天能感覺到更多的惡心和咽喉部不適等癥狀。 結(jié)論： 兩種檢測系統(tǒng)對食管酸反流的監(jiān)測方面有很強的相關(guān)性及一致性；因此國產(chǎn)食管pH膠囊可以應(yīng)用于臨床上GERD的診斷，而且延長食管pH膠囊的監(jiān)測時間能夠進一步減少測量的變異性和提高診斷敏感性。
[Abstract]:Part one
Diagnostic value of pH capsule for gastroesophageal reflux disease
Objective: To investigate the diagnostic value of domestic pH capsule in gastroesophageal reflux disease.
Methods: 28 patients who were diagnosed as gastroesophageal reflux disease (GERD) were examined by catheter type 24h esophagus pH monitoring, and the esophageal pH capsule was monitored for 1 days. The pH capsule and pH catheter probe were placed in the 6cm above the gastroesophageal junction, and the patient's tolerance to the two methods was compared and the data were analyzed and compared. Differences.
Results: two kinds of detection methods were completed in 28 cases of GERD, 4 patients were due to the technical failure of esophageal pH capsule itself, and the other 2 patients were premature falling off of pH capsule, resulting in the detection time not reaching 48h. The above 6 cases of esophageal pH monitoring data were eliminated. The remaining 22 patients successfully completed the 48h esophageal pH capsule monitoring. Patients with esophageal pH glue The tolerance of the capsule was good. And compared and analyzed the data of the two detection methods, the sensitivity of the esophageal pH capsule to GERD was 93.33%, the specificity was 85.71%, the accuracy was 90.91%. and the catheter type esophageal pH monitoring, the total pH < 4 percent time (8.5%) of the esophagus pH capsule group, the erect position pH < 4 (10.4%), the total reflux times (42.) The 6 times were significantly higher than that of the catheter group (6.4%, 6.2%, 26.4 times respectively), and the indexes were statistically different (P 0.05). The correlation between the esophageal pH capsule group and the catheter type pH monitoring group on esophageal acid reflux correlation was also significant (r=0.87, P0.0001). The pH value of the esophageal pH capsule group was 4 of the total time (8.5), pH The median time percentage (12.5) and the average number of long reflux (26.4) were significantly higher than those of the first day (4), and the indexes were statistically significant (P0.05).
Conclusion: compared with the catheter based 24h esophagus pH monitoring method, the domestic pH capsule detection method is effective and well tolerated, and the esophageal pH capsule is an ideal examination tool for the diagnosis of gastroesophageal reflux disease.
The second part
Clinical study on synchronizing catheter 24 hour esophageal pH monitoring with pH monitoring of esophageal cancer
Objective:
Objective to explore the correlation and consistency of 24 hour esophageal pH monitoring system and esophageal pH capsule monitoring system in detecting esophageal acid reflux in GERD patients.
Method錛

本文編號：1887189