本文選題：血管內(nèi)皮生長因子 + 組織三葉因子�。� 參考：《基因組學(xué)與應(yīng)用生物學(xué)》2017年08期

【摘要】：本研究探討血清中血管內(nèi)皮生長因子(VEGF)、組織三葉因子(TFF1)、胃蛋白酶原(PG)、表皮生長因子(EGF)變化及其與胃潰瘍臨床特征及愈合的關(guān)系。應(yīng)用ELISA法測定活動性胃潰瘍(n=68)、淺表性胃炎(n=60)健康對照組(n=60)血清VEGF、TFF1、PG、EGF水平。胃潰瘍組均給予雷貝拉唑三聯(lián)方案治療,治療前后均行14C-尿素呼氣試驗,胃鏡下觀察胃潰瘍患者病理特征。胃潰瘍組血清PG水平高于淺表性胃炎組及對照組(p0.05),而TFF1、VEGF、EGF水平低于淺表性胃炎組及對照組(p0.05),淺表性胃炎組血清PG水平高于對照組(p0.05)。胃潰瘍患者治療后愈合率為58.82%(40/68),HP根治率為76.47%(52/68)。治療后胃潰瘍組炎癥活動性評分、粘膜炎癥反應(yīng)評分較治療前明顯下降,而潰瘍直徑較治療前顯著減少(p0.05)。治療后未愈合組血清PG水平高于愈合組(p0.05),而TFF1、VEGF、EGF水平低于愈合組(p0.05)。治療后HP(+)組血清PG水平高于HP(-)組(p0.05),而TFF1、VEGF、EGF水平低于HP(-)組(p0.05)。經(jīng)Pearson單因素分析顯示,血清PG水平與炎癥活動性評分、粘膜炎癥反應(yīng)評分及潰瘍面積呈正相關(guān)(p0.05),而TFF1、VEGF、EGF水平與炎癥活動性評分、粘膜炎癥反應(yīng)評分及潰瘍直徑呈負(fù)相關(guān)(p0.05)。血清VEGF、TFF1、PG、EGF變化及其與胃潰瘍病理特征及愈合有密切的關(guān)系,可作為評價胃潰瘍發(fā)生及預(yù)后的有效指標(biāo)。
[Abstract]:The aim of this study was to investigate the changes of vascular endothelial growth factor (VEGF), tissue trefoil factor (TFF1), pepsinogen (PGN) and epidermal growth factor (EGF) in serum and their relationship with the clinical features and healing of gastric ulcer. ELISA method was used to determine the serum levels of VEGF, TFF1 and PGGF in patients with active gastric ulcer and control group with superficial gastritis and superficial gastritis (n ~ (60) and healthy control group (n ~ (60). All patients in gastric ulcer group were treated with rabeprazole triple regimen. 14C-urea breath test was performed before and after treatment. Pathological features of gastric ulcer patients were observed under gastroscopy. The level of serum PG in gastric ulcer group was higher than that in superficial gastritis group and control group, while the level of TFF1 VEGF EGF was lower than that in superficial gastritis group and control group. The serum PG level in superficial gastritis group was higher than that in control group. The healing rate of gastric ulcer patients after treatment was 58.82% and the radical cure rate of HP was 76.47%. After treatment, the inflammatory activity score and mucosal inflammatory response score of gastric ulcer group were significantly lower than those before treatment, and the ulcer diameter decreased significantly compared with that before treatment. After treatment, the serum PG level was higher in the unhealed group than that in the healing group, while the level of VEGF EGF in the TFF1 group was lower than that in the healing group. After treatment, the serum PG level in HP- group was higher than that in HP-) group, while the level of VEGF EGF in TFF1 group was lower than that in HP-) group. Pearson univariate analysis showed that the serum PG level was positively correlated with the inflammatory activity score, the mucosal inflammatory response score and the ulcer area, while the level of TFF1VEGFN was negatively correlated with the inflammatory activity score, the mucosal inflammatory response score and the ulcer diameter. The change of EGF in serum VEGF TFF1 is closely related to the pathological characteristics and healing of gastric ulcer. It can be used as an effective index to evaluate the occurrence and prognosis of gastric ulcer.
【作者單位】： 海南省第三人民醫(yī)院;
【基金】：海南省第三人民醫(yī)院資助
【分類號】：R573.1

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