本文選題：肝硬化 + 食管靜脈曲張�。� 參考：《石河子大學(xué)》2017年碩士論文

【摘要】：目的通過Fibro Scan(FS)測定肝硬化食管靜脈曲張患者肝、脾硬度,以及食管靜脈曲張硬化治療術(shù)后復(fù)查肝脾硬度,探討肝脾硬度與食管靜脈曲張程度的關(guān)系,同時本研究還探討了肝臟硬度于肝臟脂肪度(CAP)的相關(guān)性。方法選擇101例肝硬化患者進(jìn)行胃鏡檢查,確定無食管靜脈曲張組、輕度、中度、重度食管靜脈曲張組,并利用FS對四組患者進(jìn)行肝、脾硬度測定,并對其中11例行食管靜脈曲張硬化治療后的患者再次進(jìn)行肝、脾硬度復(fù)查,測定肝臟硬度的同時收集肝臟脂肪度。結(jié)果無食管靜脈曲張組30人,其中輕度17人,中度27人,重度27人,其肝、脾硬度均與食管靜脈曲張程度有明顯相關(guān)性,并隨食管靜脈曲張程度加重而增大,經(jīng)ROC曲線分析,肝、脾硬度曲線下面積(AUC)均大于0.7,但脾臟硬度評估中重度食管靜脈曲張最佳界值38.2KPa,曲線下面積0.958,特異度93.6%,靈敏度96.3%,95%CI為(0.919,0.997),均高于肝臟硬度。本研究對101例肝硬化患者的肝臟脂肪度測定發(fā)現(xiàn)肝臟硬度值與肝臟脂肪度的關(guān)系r=-0.138,P=0.168。結(jié)論1.利用FS測定肝、脾硬度對肝硬化患者食管靜脈曲張評估均有一定準(zhǔn)確性;2.脾臟硬度的預(yù)測效果更為準(zhǔn)確,且值得臨床進(jìn)一步研究及推廣;3.肝硬化患者肝臟硬度與肝脂肪度無明顯相關(guān)。
[Abstract]:Objective to study the relationship between hepatic and splenic hardness and esophageal varicose degree in patients with hepatic cirrhosis and esophageal varices by Fibro scanning FSs, and to determine the hardness of liver and spleen in patients with esophageal varices, and to investigate the relationship between the hardness of liver and spleen and the degree of esophageal varices after the treatment of esophageal varices. At the same time, the relationship between liver hardness and liver fat degree (CAP) was also investigated. Methods 101 patients with liver cirrhosis were examined by gastroscopy. The patients without esophageal varices, mild, moderate and severe esophageal varices were selected. The liver and spleen hardness of four groups were measured by FS. The liver and spleen hardness of 11 patients who were treated with esophageal varicosclerotic therapy were rechecked and the liver fat was collected while the liver hardness was measured. Results there were 30 patients without esophageal varices, including 17 mild, 27 moderate and 27 severe. The hardness of liver and spleen was significantly correlated with the degree of esophageal varices, and increased with the severity of esophageal varices, and was analyzed by ROC curve. The area under the hardness curve of liver and spleen was greater than 0.7, but the best threshold value of esophageal varices was 38.2 KPa. under the curve, the area under the curve was 0.958, the specificity was 93.6 and the sensitivity was 96.39.95 CI was 0.919 ~ 0.997g, which was higher than that of liver hardness. In this study, the relationship between liver hardness and liver fat was found in 101 patients with liver cirrhosis. Conclusion 1. Using FS to determine liver and spleen hardness has a certain accuracy in evaluating esophageal varices in patients with liver cirrhosis. The prediction effect of spleen hardness is more accurate and worthy of further clinical study and promotion. There was no significant correlation between liver hardness and liver fat degree in patients with liver cirrhosis.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R575.2

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本文編號：1856483