發(fā)布時間：2018-05-07 07:04

  本文選題：功能性消化不良 + 焦慮抑郁　； 參考：《華北理工大學(xué)》2017年碩士論文

【摘要】：目的本研究通過評價經(jīng)皮穴位電刺激(Transcutaneous Electrical Acupoint Stimulation,TEAS)對合并焦慮抑郁的功能性消化不良(Functional dyspepsia,FD)患者的不同指標(biāo)的療效觀察,從而為功能性消化不良的治療提供不同參考。方法1選取2015年10月至2016年8月于華北理工大學(xué)附屬醫(yī)院就診且符合羅馬Ⅲ診斷標(biāo)準(zhǔn)、焦慮抑郁評分在50-72分的病人共43例。將病人分為實驗組(經(jīng)皮穴位電刺激)與對照組(氟哌噻噸美利曲辛片),實驗組21例,對照組22例。2實驗組使用電刺激儀刺激足三里及內(nèi)關(guān)穴,每次30min,每天治療1次,每周休息1天,治療4周;對照組給予氟哌噻噸美利曲辛片口服,每日早午飯后半小時內(nèi)口服,每次劑量為10.5mg,口服4周。3以臨床癥狀積分、生活質(zhì)量評分(SF-36)、精神心理狀況評分(SAS\SDS)、飲水負荷試驗(WLT)、血清胃泌素(GAS)為觀察指標(biāo),治療前及治療后進行評估。4應(yīng)用SPSS19.0對數(shù)據(jù)進行統(tǒng)計分析。計量資料采用均數(shù)±標(biāo)準(zhǔn)差((?)±s),組內(nèi)及組間治療前后相比,采用配對t檢驗或wilcoxon檢驗,若前后差值符合正態(tài)分布,則采用配對t檢驗,若不符合正態(tài)分布,則使用wilcoxon檢驗。以P0.05或P0.01為差異有統(tǒng)計學(xué)意義。結(jié)果1兩組臨床癥狀積分比較:實驗組各項臨床癥狀積分均有下降,差異具有統(tǒng)計學(xué)意義(P0.0l);對照組在惡心、嘔吐、過度噯氣3個維度,積分較前沒有下降,治療前后不具有統(tǒng)計學(xué)意義(P0.05),在其余維度,積分均有下降,差異具有統(tǒng)計學(xué)意義(P0.0l或P0.05)。實驗組總有效率為80.95%,對照組總有效率為50%,差異有統(tǒng)計學(xué)意義(P0.05)。2兩組生活質(zhì)量評分(SF-36)比較:兩組生活質(zhì)量評分較前均有提高,差異具有統(tǒng)計學(xué)意義(P0.0l或P0.05);治療后,兩組生活質(zhì)量評分比較顯示,在生理機能、生理職能、軀體疼痛、一般健康狀況4個維度,兩組提高無統(tǒng)計學(xué)差異(P0.05),在精力、社會功能、情感職能、精神健康4個維度,對照組分數(shù)提高較實驗組提高明顯,差異具有統(tǒng)計學(xué)意義(P0.0l)。實驗組總有效率為47.62%,對照組總有效率為81.82%,差異有統(tǒng)計學(xué)意義(P0.05)。3兩組精神心理狀態(tài)評分(SAS\SDS)比較:兩組患者SAS、SDS評分較前均有下降,差異具有統(tǒng)計學(xué)意義(P0.01);對照組焦慮抑郁評分較實驗組焦慮抑郁評分下降明顯,差異具有統(tǒng)計學(xué)意義(P0.01)。4兩組飲水負荷試驗比較:與治療前相比,兩組患者的飲水量較前均有上升,差異有統(tǒng)計學(xué)意義(P0.01);對照組較實驗組飲水量上升量少,差異具有統(tǒng)計學(xué)意義(P0.01)。5兩組血清胃泌素比較:與治療前比,兩組血清胃泌素含量較前均有下降,差異具有統(tǒng)計學(xué)意義(P0.05);實驗組較對照組下降明顯,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論1經(jīng)皮穴位電刺激與氟哌噻噸美利曲辛片均是治療合并焦慮抑郁功能性消化不良患者的有效方法。2經(jīng)皮穴位電刺激在改善患者臨床癥狀方面優(yōu)于氟哌噻噸美利曲辛片。3氟噻噸美利曲辛片在改善患者焦慮抑郁及生活質(zhì)量方面優(yōu)于經(jīng)皮穴位電刺激。
[Abstract]:Objective to evaluate the efficacy of transcutaneous Electrical Acupoint stimulation (TEA) in patients with functional dyspepsia complicated with anxiety and depression, so as to provide different references for the treatment of functional dyspepsia. Methods from October 2015 to August 2016, 43 patients with anxiety and depression scores of 50-72 were selected from the affiliated Hospital of North China University of Technology. The patients were divided into two groups: experimental group (percutaneous acupoint electrical stimulation) and control group (droperazothioate metroxine tablets). The experimental group (21 cases) and the control group (22 cases) were treated with electric stimulator to stimulate Zusanli and Neiguan points for 30 minutes, once a day. The patients in the control group were treated with droperazothioate metroxine tablets for 4 weeks, and the control group with a dose of 10.5 mg within half an hour after early lunch. The clinical symptoms of the patients in the control group were scored with clinical symptoms for 4 weeks. Quality of life score (SF-36), psychosomatic score (SAS), drinking water load test (WLTT) and serum gastrin (gastrin) were used to evaluate the data before and after treatment. SPSS19.0 was used to analyze the data. The measurement data were measured by mean 鹵standard deviation) 鹵sg. The matched t test or wilcoxon test was used before and after treatment. If the difference before and after treatment was normal distribution, the paired t test was used, and if not, the wilcoxon test was used. P 0.05 or P 0.01 as the difference was statistically significant. Results 1 comparison of clinical symptom scores between the two groups: the scores of each clinical symptom in the experimental group were all decreased, the difference was statistically significant (P0.0l0. 01), in the control group, the scores of nausea, vomiting and excessive belching were not decreased. There was no statistical significance before and after treatment, but in the other dimensions, the scores were all decreased, and the difference was statistically significant (P 0.01 or P 0.05). The total effective rate of the experimental group was 80.955.The total effective rate of the control group was 50. The difference was statistically significant. The scores of quality of life in the two groups showed that there were four dimensions of physiological function, physiological function, physical pain, general health status, and there was no statistical difference between the two groups (P 0.05), and there were four dimensions of energy, social function, emotional function and mental health. The scores of the control group were significantly higher than that of the experimental group, and the difference was statistically significant (P 0.05). The total effective rate of the experimental group was 47.62 and the total effective rate of the control group was 81.82. The difference was statistically significant. The scores of anxiety and depression in the control group were significantly lower than those in the experimental group, and the difference was statistically significant in the drinking water load test between the two groups: compared with before treatment, the drinking water volume of the two groups was higher than that before treatment. There was a significant difference in serum gastrin between two groups: compared with before treatment, the content of serum gastrin in the control group was lower than that in the control group, and there was a significant difference between the control group and the experimental group in the quantity of drinking water, the difference was statistically significant (P 0.01), and the content of serum gastrin in the two groups was lower than that in the control group. The difference was statistically significant (P 0.05), and that of the experimental group was significantly lower than that of the control group (P 0.05). Conclusion 1 Percutaneous acupoint electrical stimulation and droperazothioate melitaxine tablets are effective methods for the treatment of patients with functional dyspepsia complicated with anxiety and depression. 2 Transcutaneous acupoint electrical stimulation is superior to droperazothioate in improving the clinical symptoms of patients. Ritroxine tablet .3 was superior to transcutaneous acupoint electrical stimulation in improving anxiety and depression and quality of life of patients.
【學(xué)位授予單位】：華北理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R57;R749

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