本文選題：苦參堿 + 苦參素��； 參考：《中國藥房》2017年08期

【摘要】：目的:探討苦參制劑聯(lián)合扶正化瘀膠囊對乙型肝炎(以下簡稱"乙肝")肝硬化患者肝血流動力學(xué)、纖維化指標(biāo)的影響及安全性。方法:選取2013年2月-2014年6月我院確診為乙肝肝硬化患者102例,按隨機數(shù)字表法分為聯(lián)合組和對照組,各51例。對照組患者給予阿德福韋酯膠囊10 mg,po,qd;聯(lián)合組患者在對照組基礎(chǔ)上加用扶正化瘀膠囊1.5 g,po,tid+苦參制劑(初始3個月給予苦參堿葡萄糖注射液250 m L,ivgtt,qd,3個月給予苦參素膠囊200 mg,po,tid)。兩組患者均持續(xù)治療12個月。觀察兩組患者治療前后乙肝病毒脫氧核糖核酸(HBV-DNA)、肝功能指標(biāo)[天冬氨酸轉(zhuǎn)氨酶(AST)、丙氨酸轉(zhuǎn)氨酶(ALT)、總膽紅素(TBIL)]、門靜脈血流動力學(xué)指標(biāo)[門靜脈主干內(nèi)徑(D)、平均血流速度(V)]、肝纖維化指標(biāo)[層粘連蛋白(LN)、透明質(zhì)酸(HA)、Ⅳ型膠原(Ⅳ-C)]水平,并記錄其HBV-DNA陰轉(zhuǎn)率及不良反應(yīng)發(fā)生率。結(jié)果:對照組脫落3例,共48例有效病例入組;聯(lián)合組脫落5例,共46例有效病例入組。治療前,兩組患者HBV-DNA、肝功能指標(biāo)(AST、ALT、TBIL)、肝纖維化指標(biāo)(LN、HA、Ⅳ-C)及門靜脈血流動力學(xué)指標(biāo)(D、V)水平比較,差異均無統(tǒng)計學(xué)意義(P0.05);治療后,兩組患者上述指標(biāo)水平均顯著降低,且聯(lián)合組顯著低于對照組,差異均有統(tǒng)計學(xué)意義(P0.05)。聯(lián)合組患者HBV-DNA陰轉(zhuǎn)率為93.5%,顯著高于對照組的79.2%,差異有統(tǒng)計學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:苦參制劑聯(lián)合扶正化瘀膠囊能促進(jìn)乙肝肝硬化患者肝功能恢復(fù)、調(diào)節(jié)肝區(qū)血流動力學(xué)狀態(tài)、緩解纖維化,且安全性較好。
[Abstract]:Objective: to investigate the effect and safety of Sophora flavescens preparation combined with Fuzheng Huayu capsule on hepatic hemodynamics and fibrosis in patients with liver cirrhosis. Methods: 102 patients with hepatitis B cirrhosis diagnosed in our hospital from February 2013 to June 2014 were randomly divided into two groups: the combined group and the control group (51 cases each). The patients in the control group were treated with adefovir ester capsule 10 mg / potiqdand the patients in the combined group were treated with 1. 5 g of Fuzheng Huayu capsule and 1. 5 g potid matrine preparation on the basis of the control group (3 months after administration of matrine glucose injection 250 mL) iv gttt QD, and 3 months with matrine capsule 200 mg potid. Both groups were treated continuously for 12 months. Before and after treatment, HBV-DNA, liver function index [aspartate transaminase (alt), alanine aminotransferase (alt), total bilirubin (TBIL)], portal vein hemodynamics (portal vein diameter, mean blood flow) were observed in both groups. The level of hepatic fibrosis index [laminin, hyaluronate, collagen type 鈪，

本文編號：1850925