本文選題：奧曲肽 + 前列地爾��； 參考：《重慶醫(yī)科大學》2017年碩士論文

【摘要】：目的:系統(tǒng)評價奧曲肽聯(lián)合前列地爾治療急性胰腺炎(acute pancreatitis,AP)的安全性及有效性。方法:計算機檢索PubMed、CBM、CNKI、VIP、萬方數(shù)據(jù)庫,查找有關應用奧曲肽聯(lián)合前列地爾治療急性胰腺炎的隨機對照實驗(randomized controlled trials,RCTs),同時查找符合要求文獻的引用文獻,檢索時間限制:自數(shù)據(jù)庫建立到2015年10月。2名研究人員各自篩選相關研究,同時提取所需資料及評價相關研究的質量,用RevMan 5.2軟件分析。結果:符合要求的研究18個,共計1277個患者。進行Meta分析后,其結果如下:在常規(guī)治療+奧曲肽的基礎上,加用前列地爾在以下方面效果更佳,其差異具有統(tǒng)計學意義:總有效率[RR=1.20,95%CI(1.15,1.26)],腹部癥狀緩解時間[SMD= 2.68,95%CI( 3.11, 2.25)],腹部體征緩解時間[SMD= 2.54,95%CI( 2.79, 2.30)],血淀粉酶恢復正常時間[SMD= 1.95,95%CI( 2.15, 1.76)],并發(fā)癥發(fā)生率[RR=0.30,95%CI(0.13,0.69)],平均住院時間[SMD= 8.95,95%CI( 13.61, 4.29)]。結論:本研究結果顯示,在奧曲肽的基礎上,加用前列地爾效果更佳,為急性胰腺炎的治療提供了新的選擇。但本Meta分析納入研究的病例總數(shù)較少,且大多數(shù)研究質量偏低,所以本研究所得出的結論需更多高質量的研究加以驗證。
[Abstract]:Objective: to evaluate the safety and efficacy of octreotide combined with alprostadil in the treatment of acute pancreatitis (AP). Methods: a computer-based search was made for the database of PubMedus CBM, CNKI, VIP, Wanfang. The randomized controlled trial of octreotide combined with alprostadil in the treatment of acute pancreatitis was conducted, and the citations of the required literatures were also found at the same time. Search time limit: from the establishment of the database to October 2015, 2. 2 researchers screened the relevant research, simultaneously extracted the required data and evaluated the quality of the related research, and analyzed it with RevMan 5.2 software. Results: a total of 1277 patients were enrolled in 18 studies. The results of Meta analysis were as follows: on the basis of routine treatment of octreotide, prostadil was more effective in the following aspects. 鍏跺樊寮傚叿鏈夌粺璁″鎰忎箟:鎬繪湁鏁堢巼[RR=1.20,95%CI(1.15,1.26)],鑵歸儴鐥囩姸緙撹В鏃墮棿[SMD= 2.68,95%CI( 3.11, 2.25)],鑵歸儴浣撳緛緙撹В鏃墮棿[SMD= 2.54,95%CI( 2.79, 2.30)],琛，

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