本文選題：胃食管反流病 + 橫斷面研究　； 參考：《上海交通大學(xué)》2014年博士論文

【摘要】：目的系統(tǒng)評(píng)價(jià)中國(guó)人群胃食管反流病（GERD）流行病學(xué)的臨床資料。 方法計(jì)算機(jī)檢索中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)、中國(guó)全文期刊數(shù)據(jù)庫(kù)、中國(guó)科技期刊數(shù)據(jù)庫(kù)、PubMed電子數(shù)據(jù)庫(kù)，入選2013年12月以前公開(kāi)發(fā)表的有關(guān)中國(guó)人群GERD流行病學(xué)的相關(guān)文獻(xiàn)。對(duì)納入文獻(xiàn)進(jìn)行數(shù)據(jù)提取和文獻(xiàn)質(zhì)量評(píng)估。根據(jù)納入文獻(xiàn)中GERD診斷標(biāo)準(zhǔn)進(jìn)行分組，討論中國(guó)人群GERD患病率情況，并對(duì)相關(guān)危險(xiǎn)因素與GERD之間的相關(guān)性進(jìn)行Meta分析或定性分析。Meta分析中，應(yīng)用固定效應(yīng)模型或隨機(jī)效應(yīng)模型，以比值比（OR）及其95%可信區(qū)間（CI）計(jì)算合并效應(yīng)量，以亞組分析和敏感性分析尋找異質(zhì)性來(lái)源，以漏斗圖、Begg秩相關(guān)法和Egger直線回歸法分析發(fā)表性偏倚。 結(jié)果24篇文獻(xiàn)納入系統(tǒng)評(píng)價(jià)，總體方法學(xué)質(zhì)量較好。以每周至少發(fā)生一次反流癥狀作為診斷標(biāo)準(zhǔn)時(shí)，GERD患病率為2.5%～6.2%；以蒙特利爾定義作為診斷標(biāo)準(zhǔn)時(shí)，GERD患病率為2.8%～8.4%；以胃食管反流性診斷問(wèn)卷（RDQ）≥12分為診斷標(biāo)準(zhǔn)時(shí)，GERD患病率為2.7%～10%；以SGER評(píng)分≥6分作為診斷標(biāo)準(zhǔn)，GERD患病率為5.77%～8.68%。Meta分析結(jié)果顯示，肥胖、飲酒、居住農(nóng)村地區(qū)、油膩飲食、進(jìn)食過(guò)飽、甜食、咖啡、便秘與GERD的發(fā)生呈正相關(guān)：肥胖1.75（1.51，2.04）、飲酒1.10（1.01，1.20）、農(nóng)村地區(qū)1.39（1.23，1.56）、油膩飲食1.41（1.15，1.71）、進(jìn)食過(guò)飽1.92（1.64，2.25）、甜食1.43（1.15，1.79）、咖啡1.25（1.04，1.50）、便秘1.82（1.44，2.31）；性別、吸煙、工作類(lèi)型、辛辣食物、濃茶與GERD之間無(wú)相關(guān)性：男性1.13（0.99，1.29）、吸煙1.10（0.86，1.42）、腦力工作0.92（0.68，1.23）、辛辣食物1.10（0.97，，1.26）、濃茶1.17（0.96，1.44）。定性分析結(jié)果表明，年齡大、胃腸道疾病家族史、精神狀態(tài)差、工作壓力大、食管裂孔疝、膽汁反流與GERD的發(fā)生呈正相關(guān)。部分危險(xiǎn)因素的Meta分析結(jié)果存在發(fā)表性偏倚。 結(jié)論在中國(guó)人群中進(jìn)行的GERD流行病學(xué)調(diào)查存在不同的研究設(shè)計(jì)，各地區(qū)GERD患病率有差異，但差異不大，患病率均在10%以下。肥胖、年齡大、居住農(nóng)村地區(qū)、不良生活飲食習(xí)慣、胃腸道疾病家族史、精神狀態(tài)差、工作壓力大等因素是GERD的危險(xiǎn)因素。
[Abstract]:Objective to evaluate the epidemiological data of gastroesophageal reflux disease (GERD) in Chinese population. Methods Chinese biomedical literature database, Chinese full-text journal database, Chinese sci-tech journal database and PubMed electronic database were searched by computer. The relevant literatures on GERD epidemiology of Chinese population published before December 2013 were selected. Data extraction and document quality evaluation are carried out on the included documents. According to the diagnostic criteria of GERD included in the literature, the prevalence of GERD in Chinese population was discussed, and the fixed effect model or random effect model was used to analyze the correlation between the risk factors and GERD by Meta analysis or qualitative analysis. The combined effects were calculated by ratio OR and 95% CI), heterogeneity sources were found by subgroup analysis and sensitivity analysis, and published bias was analyzed by Begg rank correlation method and Egger linear regression method. Results 24 articles were included in the systematic evaluation, and the overall quality of methodology was good. The prevalence rate of GERD was 2.5 and 6.2 using the reflux symptom at least once a week as diagnostic criterion, the prevalence rate of GERD with Montreal definition as diagnostic criterion was 2.8 and 8.4, and the GERD was divided into diagnostic criteria by RDQ 鈮

本文編號(hào)：1834678