本文選題：多藥耐藥基因 + MDR�。� 參考：《中國藥房》2017年33期

【摘要】：目的:系統(tǒng)評價多藥耐藥基因MDR1 C3435T基因多態(tài)性與質(zhì)子泵抑制劑三聯(lián)方案根除幽門螺桿菌療效的關(guān)系,為臨床提供循證參考。方法:計算機檢索Pub Med、EMBase、中國生物醫(yī)學(xué)文獻數(shù)據(jù)庫(CBM)、相關(guān)期刊論文(CJFD)、萬方數(shù)據(jù)庫、中文科技期刊數(shù)據(jù)庫(VIP),收集MDR1 C3435T基因多態(tài)性對質(zhì)子泵抑制劑三聯(lián)方案根除幽門螺桿菌感染療效的臨床研究,提取資料并按照STREGA聲明評價質(zhì)量,采用Rev Man 5.3統(tǒng)計軟件進行Meta分析。結(jié)果:共納入7項研究,合計1 019例患者。按照患者MDR1 C3435T基因型檢測結(jié)果分為野生純合子基因(CC)型組,突變雜合子基因(CT)型組與突變純合子基因(TT)型組。Meta分析結(jié)果顯示,MDR1 C3435T基因多態(tài)性中CC組、CT組與TT組患者幽門螺桿菌根除率比較,差異均無統(tǒng)計學(xué)意義[CC vs.CT:OR=0.99,95%CI(0.69,1.42),P=0.95;CC vs.TT:OR=1.44,95%CI(0.66,3.15),P=0.36;CT vs.TT:OR=1.54,95%CI(0.86,2.73),P=0.14];亞組分析發(fā)現(xiàn),亞洲人群中CT組患者幽門螺桿菌根除率顯著高于TT組,差異有統(tǒng)計學(xué)意義[OR=2.35,95%CI(1.53,3.62),P0.001]。結(jié)論:MDR1 C3435T基因多態(tài)性基本不影響質(zhì)子泵抑制劑三聯(lián)方案根除幽門螺桿菌的療效,但亞洲人群進行治療時,參考基因檢測結(jié)果有一定意義。
[Abstract]:Objective: to evaluate the relationship between the polymorphism of multidrug resistance gene MDR1 C3435T and the efficacy of proton pump inhibitor triple regimen in the eradication of Helicobacter pylori. Methods: a computerized search was conducted for Pub Meden EMBase, China Biomedical Literature Database (CBM), China Journal Full-text Database (CJFDE), and Wanfang Database. The clinical study of MDR1 C3435T gene polymorphism on proton pump inhibitor triple regimen for the eradication of Helicobacter pylori infection was carried out. The data were extracted and the quality was evaluated according to the STREGA statement. The Meta analysis was carried out by Rev Man 5.3 statistical software. Results: a total of 1 019 patients were included in 7 studies. According to the results of MDR1 C3435T genotypes, the patients were divided into wild homozygous gene group. Meta-analysis showed that there was no significant difference in the eradication rate of Helicobacter pylori between CC group and TT group in the polymorphism of MDR1 C3435T gene. The eradication rate of Helicobacter pylori in CT group was significantly higher than that in TT group (P 0.001). Conclusion the effect of proton pump inhibitor triple regimen on the eradication of Helicobacter pylori is not affected by the gene polymorphism of the 10% MDR1 C3435T gene.
【作者單位】： 樂山市人民醫(yī)院;
【基金】：四川省醫(yī)學(xué)科研青年創(chuàng)新課題(No.Q16035)
【分類號】：R573

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