本文選題：干細(xì)胞 + 炎性腸疾病��； 參考：《中國(guó)組織工程研究》2017年21期

【摘要】：背景:理論上,干細(xì)胞可以重建并調(diào)節(jié)人體免疫系統(tǒng),而且干細(xì)胞具備定向分化功能,從而有望用于治療炎癥性腸病。目的:綜述不同類(lèi)型干細(xì)胞干預(yù)炎癥性腸病的研究進(jìn)展。方法:以"干細(xì)胞,造血干細(xì)胞,間充質(zhì)干細(xì)胞,炎癥性腸病,克羅恩病,潰瘍性結(jié)腸炎"為中文檢索詞,以"stem cells transplantation,cell therapy,inflammatory bowel diseases,ulcerative colitis,Crohn’s disease"為英文檢索詞,在中國(guó)知網(wǎng)(CNKI)期刊全文數(shù)據(jù)庫(kù)、Pub Med數(shù)據(jù)庫(kù)以及FMJS數(shù)據(jù)庫(kù)檢索2002年1月至今有關(guān)干細(xì)胞移植治療炎癥性腸病的文獻(xiàn)。最終納入49篇文獻(xiàn)進(jìn)行綜述。結(jié)果與結(jié)論:胚胎干細(xì)胞與成體干細(xì)胞對(duì)炎癥性腸病均有一定的治療作用,但具體哪一種類(lèi)型的干細(xì)胞最安全、最有效以及此種細(xì)胞的最佳劑量與移植途徑等,仍需要開(kāi)展大量的研究。
[Abstract]:Background: in theory, stem cells can reconstruct and regulate the immune system, and stem cells have the function of directional differentiation, which is expected to be used in the treatment of inflammatory bowel disease. Objective: to review the progress of different types of stem cells in the intervention of inflammatory bowel disease. Methods: "stem cells, hematopoietic stem cells, mesenchymal stem cells, inflammatory bowel disease, Crohn's disease, ulcerative colitis" were used as Chinese key words, and "stem cells transplantationcell therapy and inflammatory bowel disease was used as the key word". The full text database of CNKI journal Pub Med and FMJS database were used to search the literatures about stem cell transplantation in the treatment of inflammatory bowel disease from January 2002 to present. Finally, 49 articles were reviewed. Results & conclusion: both embryonic stem cells and adult stem cells have some therapeutic effects on inflammatory bowel disease, but which type of stem cells is the safest, the most effective, the best dose and the way of transplantation, etc. A great deal of research is still needed.
【作者單位】： 成都軍區(qū)昆明總醫(yī)院細(xì)胞生物治療中心干細(xì)胞與免疫細(xì)胞生物醫(yī)藥技術(shù)國(guó)家地方聯(lián)合工程實(shí)驗(yàn)室云南省干細(xì)胞工程實(shí)驗(yàn)室云南省細(xì)胞治療技術(shù)轉(zhuǎn)化醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室昆明市干細(xì)胞與再生醫(yī)學(xué)重點(diǎn)實(shí)驗(yàn)室;昆明醫(yī)科大學(xué)成都軍區(qū)昆明總醫(yī)院臨床學(xué)院;
【基金】：國(guó)家科技支撐計(jì)劃(2014BIO1B01)~~
【分類(lèi)號(hào)】：R574

【參考文獻(xiàn)】

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