發(fā)布時(shí)間：2018-04-14 23:17

  本文選題：膽石癥 + 腸黏膜通透性��； 參考：《山東醫(yī)藥》2015年18期

【摘要】：目的探討膽石癥患者血漿和腸黏膜組織的D-乳酸及二胺氧化酶(DAO)活性變化的臨床意義。方法選擇105例膽石癥患者作為觀察組,分析結(jié)石性質(zhì),對(duì)比患者血漿和腸黏膜組織的D-乳酸及二胺氧化酶(DAO)活性,并與健康對(duì)照組比較。結(jié)果根據(jù)結(jié)石化學(xué)性質(zhì),膽色素結(jié)石患者所占比例最高,為44.76%,其次為膽固醇結(jié)石,混合性結(jié)石最低;膽色素結(jié)石患者血漿與腸黏膜的D-乳酸活性顯著低于對(duì)照組、膽固醇結(jié)石者及混合性結(jié)石者,DAO活性顯著高于對(duì)照組、膽固醇結(jié)石者及混合性結(jié)石者(P均0.05)。除膽色素結(jié)石外,不同性質(zhì)和部位的結(jié)石患者血漿與腸黏膜的D-乳酸活性及DAO活性比較差異均無(wú)統(tǒng)計(jì)學(xué)意義,與對(duì)照組相比差異亦無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論膽色素結(jié)石患者血漿與腸黏膜的D-乳酸活性較低、DAO活性較高,腸黏膜受損更嚴(yán)重。
[Abstract]:Objective to investigate the clinical significance of the changes of D-lactic acid and diamine oxidase (diamine oxidase) activity in plasma and intestinal mucosa in patients with cholelithiasis.Methods 105 patients with cholelithiasis were selected as the observation group, the stone properties were analyzed, and the activities of D-lactic acid and diamine oxidase oxidase (DAO) in plasma and intestinal mucosa of the patients were compared with those in the healthy control group.Results according to the chemical properties of the stones, the proportion of patients with pigment gallstone was the highest (44.76), the second was cholesterol stone, the lowest was mixed stone, the activity of D-lactic acid in plasma and intestinal mucosa of patients with gallstone was significantly lower than that of the control group.The activity of Dao in cholesterol calculi and mixed calculi was significantly higher than that in the control group (P < 0.05).There was no significant difference in D- lactic acid activity and DAO activity between plasma and intestinal mucosa in patients with gallstone with different properties and locations except for pigment gallstone, and there was no significant difference compared with the control group.Conclusion the activity of D-lactic acid in plasma and intestinal mucosa in patients with gallstone is higher than that in patients with choledocholithiasis, and the damage of intestinal mucosa is more serious.
【作者單位】： 莒縣人民醫(yī)院;濱州醫(yī)學(xué)院;
【基金】：濱州市科技發(fā)展計(jì)劃資助項(xiàng)目(2010ZC0768)
【分類號(hào)】：R575.62

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