本文選題：腸易激綜合征 + 難治性腸易激綜合征��； 參考：《重慶醫(yī)科大學》2014年碩士論文

【摘要】：目的:探討難治性腸易激綜合征-腹瀉型(IBS-D)的相關危險因素，為早期防治難治性IBS-D提供理論依據(jù)。 方法:將門診IBS-D患者共121例分為兩組,其中難治性IBS-D組共56例和非難治性IBS-D組共65例，對比分析兩組患者的性別、年齡、體質(zhì)量指數(shù)、家族史、吸煙史、飲酒史、癥狀嚴重程度以及焦慮抑郁狀況,通過單因素logistic回歸分析篩選出與難治性IBS-D的相關危險因素，將這些有意義的相關危險因素納入ROC曲線分析，以明確能夠預測難治性IBS-D的危險因素的臨界值。 結(jié)果:難治性IBS-D組和非難治性IBS-D組在性別、年齡、體質(zhì)量指數(shù)、家族史、吸煙史及飲酒史上比較無統(tǒng)計學意義。單因素logistic回歸分析顯示癥狀積分（OR=1.010，95%CI:1.005，1.015）、焦慮積分（OR=2.810，，95%CI:1.888，4.180）及抑郁積分（OR=1.637，95%CI:1.338，2.004）為難治性IBS-D的危險因素，ROC曲線分析顯示臨床癥狀積分、焦慮積分、抑郁積分的ROC曲線下面積（AUC）分別為0.757、0.919、0.796，其預測難治性IBS-D的臨界點分別為183分、9分、6分。故臨床癥狀積分183分、焦慮積分9分、抑郁積分6分對于預測難治性IBS-D具有重要意義。 結(jié)論:癥狀積分、焦慮積分、抑郁積分為難治性IBS-D的危險因素,可作為預測的重要參考指標。
[Abstract]:Objective: to investigate the risk factors of refractory irritable bowel syndrome (IBS-D) and to provide theoretical basis for early prevention and treatment of refractory IBS-D.Methods: a total of 121 outpatients with IBS-D were divided into two groups: 56 patients in refractory IBS-D group and 65 patients in non-refractory IBS-D group. Sex, age, body mass index, family history, smoking history and drinking history were compared between the two groups.The severity of symptoms and anxiety and depression were analyzed by univariate logistic regression analysis. The risk factors associated with refractory IBS-D were screened out, and these significant risk factors were included in the ROC curve analysis.In order to be able to predict the critical value of refractory IBS-D risk factors.Results: there was no significant difference in sex, age, body mass index, family history, smoking history and drinking history between refractory IBS-D group and non-refractory IBS-D group.Univariate logistic regression analysis showed that the symptom score was 1.0105CI: 1.005, anxiety score was 2.8105CI: 1.8884.180) and depression score OR1.637C95CI: 1.3382.004) as a risk factor for refractory IBS-D, ROC curve analysis showed that the clinical symptom score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score, anxiety score and anxiety score.The area under the ROC curve of depression score was 0.757-0.919 ~ 0.796, and the critical point of predicting refractory IBS-D was 183, 9 and 6, respectively.Therefore, the clinical symptom score of 183, anxiety score of 9 and depression score of 6 are of great significance for the prediction of refractory IBS-D.Conclusion: symptom score, anxiety score and depression score are risk factors of refractory IBS-D.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R574.4

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