本文選題：潰瘍性結(jié)腸炎 + 尼古丁��； 參考：《福建醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：系統(tǒng)評(píng)價(jià)和Meta分析尼古丁治療潰瘍性結(jié)腸炎(UC)的有效性和安全性。 方法：制定檢索策略、原始文獻(xiàn)納入標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn)，檢索外文數(shù)據(jù)庫PubMed(Medline)、Embase、OVID、the Cochrane Library；中文數(shù)據(jù)庫萬方、維普、相關(guān)期刊論文(CNKI)、谷歌學(xué)術(shù)搜索等，收集有關(guān)尼古丁治療UC的研究資料，使用改良Jadad評(píng)分量表評(píng)價(jià)納入分析的各項(xiàng)文獻(xiàn)的質(zhì)量，篩選出完全隨機(jī)對(duì)照研究文獻(xiàn)，利用統(tǒng)計(jì)軟件RevMan5.2分析尼古丁對(duì)UC誘導(dǎo)緩解的療效和安全性，計(jì)算OR值及其95％可信限范圍(CI)。 結(jié)果：檢索到相關(guān)文獻(xiàn)99篇，，其中6篇病例-對(duì)照研究文獻(xiàn)納入本meta分析。結(jié)果顯示：與標(biāo)準(zhǔn)的治療藥物(糖皮質(zhì)激素及美沙拉秦)相比，尼古丁透皮貼劑及灌腸劑對(duì)輕-中度UC患者的療效并無優(yōu)勢(OR=0.90，95%CI：0.12-6.94)，且尼古丁組的不良反應(yīng)更常見(OR=3.04，95%CI：1.94-4.78)，因?yàn)椴涣挤磻?yīng)而退出研究的患者也更多(OR=4.40，95%CI：1.35-14.40)。但是，納入2項(xiàng)研究共136例UC患者的meta分析研究顯示：尼古丁透皮貼劑的療效優(yōu)于安慰劑(OR=3.19，95%CI：1.24-8.22)。 結(jié)論：尼古丁透皮貼劑對(duì)UC誘導(dǎo)緩解的作用優(yōu)于安慰劑，但不優(yōu)于傳統(tǒng)的治療藥物(糖皮質(zhì)激素及美沙拉秦)，且尼古丁組的不良反應(yīng)更常見，限制了它的臨床應(yīng)用。
[Abstract]:Objective: to evaluate the efficacy and safety of nicotine in the treatment of ulcerative colitis by Meta.Methods: the retrieval strategy was formulated, the criteria for the inclusion of original documents and the exclusion criteria were established, and the foreign language database PubMedline Medline was searched for the Cochrane Library, the Chinese databases Wan Fang, Weip, CNKI, Google academic search, etc.To collect the data of nicotine therapy for UC, to evaluate the quality of the literature included in the analysis by using the modified Jadad score scale, and to screen out the complete randomized controlled study literature.The statistical software RevMan5.2 was used to analyze the efficacy and safety of nicotine in UC induced remission. The OR value and its 95% confidence limit were calculated.Results: 99 articles were retrieved, 6 of which were included in the meta analysis.The results showed that compared with standard therapeutic drugs (glucocorticoid and meladin),However, meta analysis of 136 UC patients included in two studies showed that the efficacy of nicotine transdermal patch was better than that of placebo OR3. 19 / 95 CI: 1.24-8.22.Conclusion: the effect of nicotine transdermal patch on UC induced relief is better than that of placebo, but not superior to traditional treatment drugs (glucocorticoid and mesalazone), and the adverse effects of nicotine group are more common, which limits its clinical application.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R574.62

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

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2 Guillermo Bastida;Belén Beltrán;;Ulcerative colitis in smokers,non-smokers and ex-smokers[J];World Journal of Gastroenterology;2011年22期

本文編號(hào)：1733315