本文選題：血吸蟲病　切入點：肝纖維化　出處：《中國血吸蟲病防治雜志》2017年03期

【摘要】：目的研究血吸蟲病患者肝纖維化與抗中性粒細胞胞質(zhì)抗體(ANCA)的關系。方法隨機選取2014年2月至2016年6月期間荊州市第一人民醫(yī)院確診的血吸蟲病患者145例作為病例組,隨機選取同期在該院體檢的健康體檢者100例作為對照組,采集兩組血清,通過間接免疫熒光法檢測ANCA,以放射免疫法檢測透明質(zhì)酸、層粘蛋白、Ⅲ型前膠原和Ⅳ型膠原,比較兩組上述指標的水平。結(jié)果病例組ANCA陽性率為28.96%(42/145),對照組為1.00%(1/100),差異有統(tǒng)計學意義(P0.05)。病例組透明質(zhì)酸、層粘蛋白、Ⅲ型前膠原和Ⅳ型膠原水平均高于對照組,4項肝纖維化指標水平異常者所占比例亦高于對照組,差異均有統(tǒng)計學意義(P均0.05)。病例組中,42例ANCA陽性者中透明質(zhì)酸、層粘蛋白水平異常者所占比例均高于ANCA陰性者;前者4項肝纖維化指標均值均高于相應正常參考值,其透明質(zhì)酸、層粘蛋白水平平均值顯著高于ANCA陰性者,差異均有統(tǒng)計學意義(P0.05)。結(jié)論血吸蟲病肝纖維化患者可出現(xiàn)自身免疫性抗體ANCA陽性,ANCA可能與肝纖維化的自身免疫過程有關。
[Abstract]:Objective to study the relationship between hepatic fibrosis and anti-neutrophil cytoplasmic antibody (ANCA) in patients with schistosomiasis.Methods from February 2014 to June 2016, 145 patients with schistosomiasis were randomly selected as the case group, and 100 healthy persons who were examined in the same period were selected as the control group. The serum samples of the two groups were collected.ANCA was detected by indirect immunofluorescence assay, hyaluronic acid, laminin, procollagen 鈪，

本文編號：1714536