本文選題：克羅恩病　切入點：磁共振動態(tài)增強(qiáng)成像　出處：《臨床放射學(xué)雜志》2015年11期

【摘要】：目的聯(lián)合磁共振定量動態(tài)增強(qiáng)(DCE-MRI)和磁共振擴(kuò)散加權(quán)成像(DW-MRI)兩種MRI功能成像對腸道克羅恩病(CD)展開研究,基于病變腸壁的病理改變,討論MRI各功能參數(shù)值的意義及功能參數(shù)之間的相關(guān)性。方法采用前瞻性研究方法,納入30例臨床確診的腸道CD患者,男21例,女9例;年齡15~72歲,平均(31.00±13.83)歲。根據(jù)常規(guī)MRI表現(xiàn),每例患者選取一段腸管行DCE-MRI和DW-MRI,在相同病變位置勾畫感興趣區(qū)(ROI)后分別得到容積轉(zhuǎn)運常數(shù)(Ktrans)、返流常數(shù)(Kep)、血管外細(xì)胞外間隙容積分?jǐn)?shù)(Ve)、血漿容量(Vp)以及表觀擴(kuò)散系數(shù)(ADC),使用Pearson相關(guān)檢驗,觀察Ktrans、Kep、Ve、Vp與ADC值之間的相關(guān)性。結(jié)果 30段病變腸管Ktrans值0.13~2.96 min-1,平均(1.16±0.77)min-1;Kep值0.14~3.39 min-1,平均(1.71±0.88)min-1;Ve值0.30~1.64,平均0.87±0.42;Vp值0.11~0.99,平均0.08±0.18;ADC值范圍0.84~2.44×10-3mm2/s,平均(1.42±0.32)×10-3mm2/s。Ktrans與ADC的相關(guān)系數(shù)0.396,P=0.030,0.05;Ve與ADC的相關(guān)系數(shù)0.507,P=0.004,0.05。結(jié)論聯(lián)合使用DCE-MRI和DW-MRI能反映CD患者腸壁微循環(huán)和微結(jié)構(gòu)改變。
[Abstract]:Objective to study the effects of DCE-MRI (quantitative dynamic enhanced Mr imaging) and DW-MRI (diffusion-weighted Mr imaging) on intestinal Crohn's disease (Crohn's disease), based on the pathological changes of the intestinal wall. Methods A prospective study was conducted in 30 patients with intestinal CD, 21 males and 9 females, aged 1572 years, with an average of 31.00 鹵13.83 years old. Each patient selected a segment of intestinal tube to perform DCE-MRI and DW-MRI. After drawing ROI at the same lesion location, the volumetric transport constants (KtransA), reflux constant (Kepa), extracellular space volume fraction (ECV), plasma volume fraction (VP) and apparent diffusive system were obtained, respectively. Using Pearson correlation test, Results the Ktrans value of 30 lesions was 0.132.96 min-1, the average value was 1.16 鹵0.77 min -1 Kep 0.143.39 min -1, the mean value of Vep was 1.71 鹵0.88 min -1V e 0.301.64, the average 0.87 鹵0.42Vp 0.110.99, the average 0.08 鹵0.18ADCs 0.84 脳 10 ~ (-3) mm ~ 2 / s, mean 1.42 鹵0.32) the correlation coefficient between 10-3mm2/s.Ktrans and ADC was 0.396nP0.0300.05Ve and ADC 0.0040.05Ve. Combined use of DCE-MRI and DW-MRI can reflect the changes of intestinal wall microcirculation and structure in CD patients.
【作者單位】： 南京醫(yī)科大學(xué)第二附屬醫(yī)院放射科;南京醫(yī)科大學(xué)第二附屬醫(yī)院腸病中心;通用電氣藥業(yè)(
【基金】：江蘇省科技專項(編號:BL2014097)
【分類號】：R445.2;R574.62

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本文編號：1696371