本文選題：非酒精性脂肪肝病　切入點(diǎn)：腸道菌群　出處：《中國(guó)老年學(xué)雜志》2017年23期

【摘要】：目的探討益生菌對(duì)非酒精性脂肪肝病(NAFLD)患者細(xì)胞因子及腸道菌群的影響及益生菌治療NAFLD的療效。方法選取NAFLD患者70例,采用隨機(jī)數(shù)字表法分為常規(guī)治療(A)組和聯(lián)合治療(B)組各35例。A組予多烯磷脂酰膽堿膠囊,B組予多烯磷脂酰膽堿膠囊聯(lián)合口服枯草桿菌二聯(lián)活菌腸溶膠囊。另納入同期于該院體檢者40例為對(duì)照(NC)組。比較3組間一般指標(biāo)、腸道菌群、雙歧桿菌/大腸桿菌(B/E)值、總膽固醇(TC)、甘油三酯(TG)、丙氨酸轉(zhuǎn)氨酶(ALT)、門(mén)冬氨酸轉(zhuǎn)氨酶(AST)、胰島素抵抗(IR)指數(shù)(HOMA-IR)、白細(xì)胞介素(IL)-18、干擾素(IFN)-γ及IL-10水平。結(jié)果治療前A、B組WC、BMI,TC、TG、HOMA-IR、ALT、AST、IL-18及IFN-γ水平均顯著高于NC組,而腸道菌群數(shù)、B/E及IL-10水平明顯低于NC組(P0.05);治療后A、B組以上各指標(biāo)水平均有改善,除B/E外,B組以上各指標(biāo)改善均比A組更明顯(P0.05)。結(jié)論 NAFLD患者血脂代謝絮亂、轉(zhuǎn)氨酶及IR異常、腸道菌群及機(jī)體抗炎/促炎因子失調(diào),益生菌可有效改善以上狀態(tài)。
[Abstract]:Objective to investigate the effects of probiotics on cytokines and intestinal flora in patients with nonalcoholic fatty liver disease (NAF LDD) and the efficacy of probiotics in the treatment of NAFLD. The random digital table method was used to divide the two groups into routine treatment group (35 cases) and combined treatment group (35 cases). Group A was given polyenylphosphatidylcholine capsules (group B) and oral enteric capsules of Bacillus subtilis (Bacillus subtilis) combined with polyphosphatidylcholine capsule (group B). At the same time, 40 cases of physical examination in this hospital were used as control group. The general indexes were compared among the three groups. Intestinal flora, Bifidobacterium / Escherichia coli B / E, Results the levels of HOMA-IRN, IL-18, IFN- 緯, IFN- 緯 and TBMI-TGG in AB group were significantly higher than those in NC group before treatment, and the levels of Homa, IL-18, IFN- 緯 and IFN- 緯 in AB group were significantly higher than those in NC group before treatment, and there were no significant differences between the two groups before treatment, and the levels of IL-18 and IFN- 緯 in AB group were significantly higher than those in NC group before treatment, the levels of IL-18 and IFN- 緯 were significantly higher in AB group than those in NC group, and the levels of IL-18 and IFN- 緯 were significantly higher in group A than those in group C before treatment. However, the levels of B- / E and IL-10 in intestinal microflora were significantly lower than those in NC group (P 0.05), and the above indexes in group A and B were all improved after treatment, and the improvement of above indexes in group B was more obvious than that in group A (P 0.05). Conclusion the levels of lipid metabolism, transaminase and IR were abnormal in NAFLD patients. Intestinal flora and anti-inflammatory / pro-inflammatory factor disorder, probiotics can effectively improve the above state.
【作者單位】： 海南省人民醫(yī)院消化內(nèi)科;中南大學(xué)湘雅三醫(yī)院消化內(nèi)科;
【分類(lèi)號(hào)】：R575.5

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