本文選題：甲亢　切入點(diǎn)：肝功能損害　出處：《廣西醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的：分析甲狀腺功能亢進(jìn)癥患者出現(xiàn)肝功能損害的原因、臨床表現(xiàn)、影響因素，為臨床診治甲亢出現(xiàn)肝功能損害提供指導(dǎo)。 方法：總結(jié)我院內(nèi)分泌代謝病科2012年3月至2014年2月收治的122例甲亢病例，根據(jù)肝功能檢測(cè)結(jié)果分為肝功能正常組（A組51例）和肝功能損害組（B組71例），比較兩組病例的一般情況、肝功能指標(biāo)及甲狀腺功能指標(biāo)，，分析71例甲亢患者出現(xiàn)肝功能損害的臨床資料，并對(duì)各因素進(jìn)行相關(guān)分析。 結(jié)果：B組71例甲亢患者出現(xiàn)肝功能損害中，甲亢所致有52例（占73.2％）、抗甲亢藥物（ATD）所致有16例（占22.5％）、甲亢合并病毒性肝炎所致有2例（占2.8％）、甲亢合并自身免疫性肝病所致有1例（占1.4％）。A、B兩組患者的性別、年齡、病程、FT3、FT4、TT3、TT4、TSH、ALT、AST、ALP進(jìn)行比較分析，B組患者的FT4、TT3、TT4、TSH、ALT、AST、ALP高于A組，尤以FT4和TSH為顯著，存在顯著性差異（P0.01）。甲亢所致肝功能損害組肝功能指標(biāo)的相關(guān)性分析，經(jīng)SPSS計(jì)算，AST與FT3、FT4、TT3呈正相關(guān)，P0.05； ALT與FT3、FT4、TT3、TT4呈正相關(guān)，P0.05。各病因所致肝功能損害各有其臨床特點(diǎn)，予積極治療原發(fā)病及病因治療后肝功能多能恢復(fù)正常。 結(jié)論：甲亢患者出現(xiàn)肝功能損害病因各有不同，以甲亢所致肝功能損害者多見(jiàn)，肝功能損害和甲狀腺激素水平升高有密切關(guān)系。
[Abstract]:Objective: to analyze the causes, clinical manifestations and influencing factors of liver function damage in hyperthyroidism patients, and to provide guidance for the diagnosis and treatment of hyperthyroidism. Methods: 122 cases of hyperthyroidism from March 2012 to February 2014 in our department of endocrine and metabolic diseases were summarized. According to the results of liver function test, the patients were divided into normal group (n = 51) and group B (n = 71). The general condition, liver function index and thyroid function index were compared between the two groups. The clinical data of 71 patients with hyperthyroidism were analyzed and the related factors were analyzed. Results in group B, 71 patients with hyperthyroidism had liver function damage. There were 52 cases of hyperthyroidism (73.2%), 16 cases of antihyperthyroidism (22.5%), 2 cases of hyperthyroidism complicated with viral hepatitis (2.8T), 1 case of hyperthyroidism complicated with autoimmune liver disease (1.4%). The course of the disease FT _ 3 / T _ 3H _ T _ 3T _ 4 / T _ 4 T _ 4 T _ (4) T _ (4) T _ (4) T _ (3) T _ (4) T _ (4) T _ (4) T _ (T) ALP in patients with hyperthyroidism was higher than that in group A, especially in FT4 and TSH, and there was significant difference between them (P0.01. the correlation analysis of liver function indexes in hyperthyroidism group) was also carried out in the patients with hyperthyroidism. There was a positive correlation between SPSS and FT _ 3T _ 4T _ 3 and ALT and FT _ 3T _ 4 / TT _ 3T _ 4.The liver function damage caused by each etiology had its own clinical characteristics, and the liver function returned to normal after active treatment and etiological treatment. Conclusion: the etiology of liver function damage in patients with hyperthyroidism is different. The liver function damage caused by hyperthyroidism is more common, and the liver function damage is closely related to the increase of thyroid hormone level.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R581.1;R575

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