本文選題：奧美拉唑　切入點：阿莫西林　出處：《中國藥房》2016年30期

【摘要】：目的:觀察3種用藥方案治療幽門螺桿菌(Hp)感染活動性慢性胃炎的Hp根除情況和安全性。方法:150例Hp感染活動性慢性胃炎患者隨機分為A組(50例)、B組(50例)和C組(50例)。A組患者給予奧美拉唑腸溶膠囊20 mg,口服,每日2次+阿莫西林膠囊1.0 g,口服,每日3次+克拉霉素片0.5 g,口服,每日1次。B組患者在A組治療的基礎(chǔ)上給予膠體果膠鉍膠囊150 mg,口服,每日3次。C組患者第1~5天給予奧美拉唑腸溶膠囊20 mg,口服,每日2次+阿莫西林膠囊1.0 g,口服,每日3次,第6~10天給予奧美拉唑腸溶膠囊20 mg,口服,每日2次+克拉霉素片0.5 g,口服,每日1次+甲硝唑片0.4 g,每日2次。各組患者療程均為10 d。觀察各組患者疼痛緩解有效率、疼痛緩解時間、消化道癥狀緩解時間、Hp根除率、隨訪12個月的復發(fā)情況及不良反應發(fā)生情況。結(jié)果:疼痛緩解有效率、Hp根除率C組B組A組,疼痛緩解時間、消化道癥狀緩解時間、復發(fā)率C組B組A組,差異均有統(tǒng)計學意義(P0.05)。不良反應發(fā)生率C組A、B組,差異均有統(tǒng)計學意義(P0.05),但A、B組間比較差異無統(tǒng)計學意義(P0.05)。結(jié)論:分階段服用奧美拉唑聯(lián)合抗菌藥物治療Hp感染活動性慢性胃炎可有效緩解患者胃部疼痛,縮短病程,提高Hp根除率,降低遠期復發(fā)率,且安全性較好。
[Abstract]:Objective: to observe the eradication and safety of HP in the treatment of active chronic gastritis with Helicobacter pylori (HP) infection. Methods: 150 patients with active chronic gastritis with HP infection were randomly divided into two groups: group A (n = 50) and group B (n = 50). Group A (n = 50) received omeprazole enteric-coated capsule (20mg) orally. Amoxicillin capsules 1.0 g, oral, clarithromycin tablets 0.5 g, oral, group B once a day, on the basis of treatment in group A, 150 mg colloidal bismuth pectin capsules were given orally. The patients in group C were given omeprazole enteric-coated capsule 20 mg daily, amoxicillin capsule 1.0 g twice daily, three times daily, and omeprazole enteric-coated capsule 20 mg on day 610. Clarithromycin tablets 0.5 g daily, oral, metronidazole tablets 0.4 g once daily, twice daily. The course of treatment was 10 days. The effective rate of pain relief, the time of pain relief, the time of remission of digestive tract symptoms and the eradication rate of HP were observed. Results: the effective rate of pain relief and HP eradication rate group C group B group, pain relief time, digestive tract symptom relief time, recurrence rate C group B group A group. The incidence of adverse reactions in group C was significantly higher than that in group A (P 0.05). The difference was statistically significant (P 0.05), but there was no significant difference between group A and group B (P 0.05). Conclusion: Omeprazole combined with antimicrobial agents in the treatment of active chronic gastritis with HP infection can effectively relieve the pain of stomach and shorten the course of disease in patients with HP infection. It is safe to improve HP eradication rate and reduce long-term recurrence rate.
【作者單位】： 武漢市黃陂區(qū)人民醫(yī)院;
【分類號】：R573.3

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