本文選題：急性胰腺炎　切入點：生長激素釋放肽　出處：《山東醫(yī)藥》2017年24期 　論文類型：期刊論文

【摘要】：目的探討急性胰腺炎(AP)患者血清生長激素釋放肽(Ghrelin)、脂氧素A4(LXA4)水平變化及其臨床意義。方法選擇AP患者120例,其中輕癥54例(輕癥AP組)、重癥66例(重癥AP組),住院期間死亡12例(均為重癥AP);另選體檢健康者60例為對照組。采用ELISA法檢測血清Ghrelin、LXA4,采用受試者工作特征(ROC)曲線分析血清Ghrelin、LXA4對AP的診斷價值。結(jié)果輕、重癥AP組治療前血清Ghrelin水平均高于對照組,重癥AP組高于輕癥AP組;LXA4水平均低于對照組,重癥AP組低于輕癥AP組;治療第3、5、7天,輕、重癥AP組血清Ghrelin水平呈逐漸降低趨勢,血清LXA4水平呈逐漸升高趨勢,重癥AP組變化更明顯;組間及組內(nèi)比較P均0.05。住院期間死亡的AP患者入院時血清Ghrelin水平高于、LXA4水平低于存活者(P均0.01)。血清Ghrelin診斷AP的ROC曲線下面積(AUC)為0.710,敏感性為76.3%,特異性為85.5%,準確性為80.4%;血清LXA4診斷AP的AUC為0.728,敏感性為70.8%,特異性為89.2%,準確性為88.2%。結(jié)論 AP患者血清Ghrelin水平升高、LXA4水平降低;檢測二者水平變化有助于AP診斷、病情判斷及患者預(yù)后評估。
[Abstract]:Objective to investigate the changes and clinical significance of serum growth hormone releasing peptide (ghrelin) and lipoxygenin A _ 4 (LXA4) in patients with acute pancreatitis (AP). Methods 120 patients with AP were selected. 54 cases of mild disease (mild AP group, 66 cases of severe disease (severe AP group, 12 cases of death in hospital; 60 cases of health check group as control group). Serum ghrelin LXA4 was detected by ELISA method, and the operating characteristics of subjects were used to detect the serum ghrelin LXA4. The diagnostic value of serum ghrelin LXA4 in AP was mild. The level of serum Ghrelin in severe AP group was higher than that in control group before treatment, the level of serum Ghrelin in severe AP group was lower than that in mild AP group, and that in severe AP group was lower than that in mild AP group. The level of serum LXA4 increased gradually, especially in severe AP group. The serum Ghrelin level of AP patients who died during hospitalization was higher than that of survivors (P < 0.01). The area under ROC curve of serum Ghrelin diagnosis of AP was 0.710, the sensitivity was 76.3and the specificity was 85.5. The AUC, sensitivity, specificity and accuracy of serum LXA4 in the diagnosis of AP were 0.728, 88.2 and 88.2.Conclusion the level of serum Ghrelin in AP patients increased and the level of LXA4 decreased. Detection of both levels is helpful for AP diagnosis, diagnosis and prognostic evaluation.
【作者單位】： 山東醫(yī)學(xué)高等專科學(xué)校;山東省立醫(yī)院;
【基金】：山東省教育廳科研資助課題(J09LF29)
【分類號】：R576

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