本文選題：高脂血癥性胰腺炎　切入點(diǎn)：血漿置換　出處：《中國藥房》2017年30期 　論文類型：期刊論文

【摘要】：目的:探討血漿置換聯(lián)合胰島素強(qiáng)化降糖對高脂血癥性胰腺炎患者相關(guān)指標(biāo)的影響。方法:120例高脂血癥性胰腺炎患者隨機(jī)分為對照組(60例)和觀察組(60例)。兩組患者在常規(guī)治療的基礎(chǔ)上,于入住重癥監(jiān)護(hù)病房(ICU)72 h內(nèi)連續(xù)進(jìn)行3次血漿置換+皮下注射注射用低分子肝素鈣5 000單位+靜脈推注注射用甲潑尼龍琥珀酸鈉40 mg和葡萄糖酸鈣注射液2 g。在此基礎(chǔ)上,對照組患者隨機(jī)血糖濃度≥12 mmol/L時(shí),給予胰島素注射液,微量泵泵入至隨機(jī)血糖12 mmol/L;觀察組患者隨機(jī)血糖濃度8.3 mmol/L時(shí),給予胰島素注射液,微量泵持續(xù)靜脈輸注1周,維持隨機(jī)血糖濃度在6.1~8.3 mmol/L。觀察兩組患者治療前后血漿三酰甘油、淀粉酶、降鈣素原水平和白細(xì)胞計(jì)數(shù)、全身評(píng)分系統(tǒng)研究評(píng)分(APACHEⅡ)、局部評(píng)分系統(tǒng)研究(Balthazar CT)評(píng)分、ICU住院時(shí)間及不良反應(yīng)發(fā)生情況。結(jié)果:治療后,兩組患者血漿三酰甘油、淀粉酶、降鈣素原水平和白細(xì)胞計(jì)數(shù)、APACHEⅡ評(píng)分、Balthazar CT評(píng)分均顯著低于同組治療前,且觀察組顯著低于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組患者ICU住院時(shí)間顯著短于對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組患者不良反應(yīng)發(fā)生率比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:血漿置換聯(lián)合胰島素強(qiáng)化降糖能有效降低高脂血癥性胰腺炎患者血漿三酰甘油水平,緩解炎癥反應(yīng),改善預(yù)后,且未增加不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to investigate the effect of plasma exchange combined with insulin intensive hypoglycemia on the related indexes of hyperlipidemic pancreatitis. Methods: 120 cases of hyperlipidemic pancreatitis were randomly divided into two groups: control group (n = 60) and observation group (n = 60). On the basis of routine treatment, Within 72 hours after admission to intensive care unit (ICU), three consecutive plasma exchange subcutaneous injection of low molecular weight heparin calcium 5 000 units of sodium methylprednisolone succinate 40 mg and calcium gluconate injection 2 g were performed. The patients in the control group were given insulin injection at random blood glucose concentration 鈮，

本文編號(hào)：1642567