本文選題：乙型肝炎　切入點(diǎn)：胰腺癌　出處：《中華醫(yī)院感染學(xué)雜志》2015年14期 　論文類型：期刊論文

【摘要】：目的研究胰腺癌患者乙型肝炎病毒感染行介入治療的療效及生存率。方法選擇2011年5月-2014年1月收治的94例胰腺癌合并乙型肝炎患者,按照入院順序?qū)⒒颊叻譃橛^察組和對(duì)照組各47例,對(duì)照組患者給予手術(shù)治療,觀察組患者則采取介入治療,依據(jù)實(shí)體瘤的療效評(píng)價(jià)標(biāo)準(zhǔn)(RECIST)對(duì)兩組患者治療之后的療效進(jìn)行比較分析,檢測(cè)兩組患者在治療后的免疫抑制酸性蛋白(IAP)和可溶性腫瘤壞死因子受體Ⅳ(sTNFR-Ⅳ)的情況,比較兩組患者治療后的生存率。結(jié)果患者治療療效率觀察組為78.72%、對(duì)照組為48.94%,兩組比較差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療后觀察組患者的IAP和sTNFR-IV水平顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療2、5、10個(gè)月后兩組患者的HBV-DNA水平明顯下降,且觀察組顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);觀察組患者在6個(gè)月的生存率為95.74%,顯著高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論胰腺癌合并乙型肝炎患者行介入治療之后其療效較好,具有較高的生存率。
[Abstract]:Objective to study the curative effect and survival rate of pancreatic cancer with interventional treatment in patients with hepatitis B virus infection. Methods in May 2011 94 cases with pancreatic cancer and hepatitis B patients with -2014 admitted in January, according to the order of admission were divided into observation group and control group with 47 cases in each group, the control group were treated with surgical treatment, patients in the observation group was taken to intervene on the basis of treatment, solid tumor efficacy evaluation criteria (RECIST) to compare and analyze the curative effect after treatment of the two groups, two groups were detected in immune after treatment of immunosuppressive acidic protein (IAP) and soluble tumor necrosis factor receptor IV (sTNFR- IV) cases, the survival rate of two groups were compared after treatment. Patients with treatment efficiency was 78.72% in the observation group, the control group was 48.94%, there was significant difference between two groups (P0.05); after treatment, the observation group of patients with IAP and sTNFR-IV were significantly lower than the control group, difference There was a significant correlation (P0.05); the HBV-DNA level of two groups of patients 2,5,10 months after treatment decreased significantly, and the observation group was significantly lower than the control group, the difference was statistically significant (P0.05); the patients in observation group were 6 months survival rate was 95.74%, significantly higher than the control group, the difference was statistically significant (P0.05). For patients with hepatitis B conclusion pancreatic cancer Interventional therapy after its curative effect is better, the survival rate is high.

【作者單位】： 鄭州大學(xué)附屬腫瘤醫(yī)院介入科;
【基金】：河南省科技廳研究基金資助項(xiàng)目(HNKJ78245-024)
【分類號(hào)】：R735.9;R512.62

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

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本文編號(hào)：1584097