本文關(guān)鍵詞： 脂肪肝 臭氧 瘦素 外科手術(shù)中自體血液回收 組織構(gòu)建 組織工程 非酒精性脂肪肝 一氧化氮 前列腺素F-a 白細(xì)胞介素 高敏C-反應(yīng)蛋白 氧化低密度脂蛋白 國家自然科學(xué)基金　出處：《中國組織工程研究》2015年07期 　論文類型：期刊論文

【摘要】：背景:臭氧溶于血液治療疾病目前已作為指南之外的補(bǔ)充治療或者輔助治療方法,但研究報(bào)告多為臨床療效描述性觀察,臭氧治療是否影響血清細(xì)胞因子尚不清楚。目的:觀察臭氧自體血回輸治療對(duì)非酒精性脂肪肝患者血清一氧化氮、前列腺素F-2a、白細(xì)胞介素6、高敏C-反應(yīng)蛋白、氧化低密度脂蛋白、瘦素的影響。方法:選取2013年10月至2014年6月于新疆醫(yī)科大學(xué)第一附屬醫(yī)院肝病科住院治療的非酒精性脂肪肝患者36例,按患者意愿分為臭氧治療組和對(duì)照組,對(duì)照組單獨(dú)護(hù)肝藥物治療,治療組在護(hù)肝藥物治療基礎(chǔ)上加用臭氧自體血回輸治療,所有伴有2型糖尿病和(或)血脂紊亂的入選者均接受專業(yè)的降糖和(或)降脂治療,測定所有入選者治療前后血清一氧化氮、前列腺素F-2a、白細(xì)胞介素6、高敏C-反應(yīng)蛋白、氧化低密度脂蛋白、瘦素水平。結(jié)果與結(jié)論:與對(duì)照組相比,治療組患者治療前血清中前列腺素F-2a和瘦素水平較高(P≤0.05),治療前后兩組患者瘦素差值水平差異無顯著性意義(P0.05),而前列腺素F-2a治療前后差值水平差異仍具有顯著性意義(P=0.02)。提示臭氧自體血回輸治療可降低非酒精性脂肪肝患者瘦素水平,改善非酒精性脂肪肝患者瘦素抵抗,對(duì)非酒精性脂肪性肝病患者遠(yuǎn)期預(yù)后可能有預(yù)防及治療作用。
[Abstract]:Background: ozone dissolved in blood has been used as a supplementary or adjuvant therapy for diseases outside of the guidelines, but most of the research reports are descriptive observations of clinical efficacy. Objective: to observe the effects of ozone autotransfusion on serum nitric oxide, prostaglandin F-2a, interleukin-6, Gao Min C-reactive protein in patients with non-alcoholic fatty liver. Effects of oxidized low density lipoprotein (LDL) and leptin. Methods: from October 2013 to June 2014, 36 patients with non-alcoholic fatty liver were enrolled in the Department of Hepatology, the first affiliated Hospital of Xinjiang Medical University. According to the wishes of the patients, the patients were divided into the ozone treatment group and the control group, the control group was treated with liver protection drugs alone, and the treatment group was treated with ozone autologous blood transfusion on the basis of the liver protection drug therapy. All patients with type 2 diabetes mellitus and / or dyslipidemia received professional hypoglycemic and / or lipid lowering therapy. Serum nitric oxide, prostaglandin F-2a, interleukin-6, Gao Min C-reactive protein were measured before and after treatment. Levels of oxidized low density lipoprotein and leptin. Results and conclusions: compared with the control group, The serum levels of prostaglandin F-2a and leptin in the treatment group were higher than those in the control group (P 鈮，

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