本文關鍵詞： 比阿培南 治療 肝衰竭 重度感染　出處：《中華醫(yī)院感染學雜志》2015年23期 　論文類型：期刊論文

【摘要】：目的研究肝衰竭重度感染患者病原菌的分布,探討其危險因素、臨床特點及治療轉歸,評價比阿培南治療肝衰竭重度感染患者的療效性和安全性。方法選取2012年2月-2015年1月在醫(yī)院住院的306例肝衰竭重度感染患者,對常見感染指標進行監(jiān)測,并對采集的標本進行細菌培養(yǎng),應用比阿培南治療,觀察臨床表現(xiàn)變化、療程及不良反應發(fā)生情況,數(shù)據(jù)采用SPSS 11.5軟件進行統(tǒng)計分析。結果 306例肝衰竭重度感染患者中自發(fā)性細菌腹膜炎占64.71%,呼吸道感染占26.47%,其他部位感染占8.82%;大腸埃希菌在血液、腹水及尿液培養(yǎng)中分別占40.39%、58.69%、50.00%;而肺炎鏈球菌在痰液培養(yǎng)最常見為29.41%;應用比阿培南治療一周總有效率為89.22%、痊愈率為63.73%,治療兩周總有效率為91.50%、痊愈率為86.27%。結論肝衰竭患者感染發(fā)生率高,預后差,最常見的重度感染為自發(fā)性細菌性腹膜炎;比阿培南治療肝衰竭合并重度感染患者安全有效且不良反應少。
[Abstract]:Objective to study the distribution of pathogenic bacteria in patients with severe infection of liver failure, and to explore the risk factors, clinical characteristics and outcome of treatment. Objective: to evaluate the efficacy and safety of Biapenem in the treatment of severe infection of liver failure. Methods 306 patients with severe infection of liver failure who were hospitalized from February 2012 to January 2015 were selected and the common infection indexes were monitored. The samples were cultured and treated with Biapenem. The clinical manifestations, course of treatment and adverse reactions were observed. Results among the 306 patients with severe infection of liver failure, spontaneous bacterial peritonitis accounted for 64.71%, respiratory tract infection 26.47%, other infection 8.82%, Escherichia coli in blood. Ascitic fluid and urine culture accounted for 40.39 and 58.69 respectively, while Streptococcus pneumoniae was the most common in sputum culture 29.41. The total effective rate was 89.222.The cure rate was 63.730.The total effective rate for two weeks was 91.50 and the cure rate was 86.27.Conclusion the total effective rate is 89.22, the cure rate is 63.73, the total effective rate is 91.50 and the cure rate is 86.271.Conclusion liver failure is a disease of liver failure. The incidence of infection was high, The prognosis was poor and the most common severe infection was spontaneous bacterial peritonitis, which was safer, more effective and less adverse than Apenem in the treatment of liver failure complicated with severe infection.
【作者單位】： 山東大學附屬濟南市傳染病醫(yī)院介入科;章丘市人民醫(yī)院內科;山東大學附屬濟南市傳染病醫(yī)院肝病科;
【基金】：山東省科技廳研究基金資助項目(201409882)
【分類號】：R575.3

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