本文關(guān)鍵詞：清熱和胃理氣降逆法聯(lián)合PPI治療胃食管反流病肝胃郁熱證的臨床療效觀察與機(jī)理探討　出處：《南京中醫(yī)藥大學(xué)》2015年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 清熱和胃理氣降逆法 胃食管反流病 肝胃郁熱證 臨床觀察

【摘要】：目的：觀察清熱和胃理氣降逆法聯(lián)合PPI治療胃食管反流病肝胃郁熱證的臨床療效及對生活質(zhì)量的影響,并根據(jù)現(xiàn)代藥理研究探討清熱和胃理氣降逆法的作用機(jī)理。方法：將符合納入標(biāo)準(zhǔn)的60例患者,隨機(jī)分為對照組和治療組,每組30例,對照組給予雷貝拉唑鈉腸溶片,治療組予中藥清熱和胃理氣降逆聯(lián)合雷貝拉唑鈉腸溶片,療程8周,采用問卷調(diào)查方式,觀察并記錄治療前后各組主要癥狀、次要癥狀及生活質(zhì)量積分,進(jìn)行療效評定。全部數(shù)據(jù)以SPSS17.0統(tǒng)計軟件進(jìn)行統(tǒng)計學(xué)分析。結(jié)果：1.治療后改善主要綜合癥狀積分的總有效率治療組和對照組分別為93.3%和70.0%,前者顯著高于后者(P0.01)。2.兩組均能降低主要單項(xiàng)癥狀積分(P0.01 或P0.05),治療組緩解反流癥狀的療效顯著優(yōu)于對照組(P0.01),而燒心、胸痛、反酸三癥改善情況。兩組無顯著差異(P0.05)。3.治療后改善次要癥狀積分的總有效率治療組和對照組分別為96.7%和76.7%,前者顯著高于后者(P0.01)。4.兩組均能顯著降低胃食管反流病患者的生活質(zhì)量積分(P0.01),治療組提高胃食管反流病患者生活質(zhì)量的療效明顯優(yōu)于對照組(P0.01)。結(jié)論：清熱和胃理氣降逆法聯(lián)合PPI療效顯著,可顯著改善肝胃郁熱型胃食管反流病患者的臨床癥狀,提高患者生活質(zhì)量,安全性較高長期服用未見明顯不良事件,值得進(jìn)一步研究推廣。
[Abstract]:Objective: To observe the clinical curative effect of clearing heat and regulating the stomach drop inverse method combined with PPI in the treatment of gastroesophageal reflux disease heat stagnation of liver and stomach and the influence on the quality of life, and according to modern pharmacological research to explore the mechanism of clearing heat and regulating the stomach drop inverse method. Methods: the 60 patients meeting the inclusion criteria were randomly divided into control group and treatment group, 30 cases in each group, the control group was given Rabeprazole Sodium Enteric-coated Tablets, treatment group was treated with traditional Chinese medicine and regulating the stomach drop inverse joint Rabeprazole Sodium Enteric-coated Tablets, after 8 weeks of treatment, by means of questionnaire survey, observe and record the main symptoms of each group before and after treatment, secondary symptoms and quality of life score, the efficacy was evaluated. All data were statistically analyzed by SPSS17.0 software. Results: the main symptoms improved 1. points after treatment the total effective rate of the treatment group and control group were 93.3% and 70%, the former was significantly higher than that of the latter (P0.01).2. The two groups can reduce the main individual symptom scores (P0.01 or P0.05), treatment group, remission of reflux symptoms was significantly better than the control group (P0.01), and heartburn, chest pain, acid regurgitation, three improvement. The two groups had no significant difference (P0.05) to improve the secondary symptom score after.3. treatment the total effective rate of the treatment group and the the control group were 96.7% and 76.7%, the former was significantly higher than that of the latter (P0.01.4.) of two groups were significantly reduced in patients with gastroesophageal reflux disease (P0.01) score of quality of life to improve the curative effect of gastroesophageal reflux, the life quality of patients was significantly better than the control group in the treatment group (P0.01). Conclusion: clearing heat and regulating the stomach significantly drop inverse method combined with PPI effect, can improve the clinical symptoms of liver and stomach swelter type gastroesophageal reflux disease patients, improve the quality of life of patients, higher safety of long-term use of no obvious adverse events, it is worthy of further study.

【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R571

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本文編號：1419715