本文關(guān)鍵詞：烏司他丁靜脈滴注聯(lián)合生大黃煎液灌腸對重癥胰腺炎患者的療效及炎癥因子水平的改善效果分析　出處：《中華中醫(yī)藥學(xué)刊》2016年07期 　論文類型：期刊論文

  更多相關(guān)文章： 烏司他丁 生大黃 重癥胰腺炎 炎癥因子 療效

【摘要】：目的:探究烏司他丁靜脈滴注聯(lián)合生大黃煎液灌腸對重癥胰腺炎患者的療效及炎癥因子水平的改善效果。方法:隨機選取2009年6月—2013年6月醫(yī)院收治的62例重癥胰腺炎患者作為本次研究對象,根據(jù)入院時間先后將患者分成觀察組和對照組各31例,對照組采用烏司他丁治療,觀察組采用烏司他丁聯(lián)合大黃煎液灌腸治療,觀察并記錄兩組患者臨床療效,臨床癥狀消退時間以及腫瘤壞死因子α(TNF-α)、白細(xì)胞介素-6(IL-6)和白細(xì)胞介素-8(IL-8)等指標(biāo)變化情況,分析比較。結(jié)果:治療后,觀察組共治愈15例,總有效率達(dá)93.55%,對照組總有效率只有74.19%,兩組比較有統(tǒng)計學(xué)意義(P0.05)。兩組患者治療后TNF-α、IL-6和IL-8含量較治療前均有顯著下降,且觀察組明顯低于對照組患者,兩組比較有統(tǒng)計學(xué)意義(P0.05)。經(jīng)治療后所有患者血清淀粉酶、谷丙轉(zhuǎn)氨酶和白細(xì)胞計數(shù)較治療前均有顯著降低(P0.05),且觀察組與對照組比較有明顯差異(P0.05)。觀察組患者腹痛、排氣和排便等臨床癥狀恢復(fù)時間均明顯低于對照組患者,兩組比較有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:烏司他丁聯(lián)合大黃煎液灌腸治療重癥胰腺炎患者臨床療效較好,各項臨床癥狀在短時間內(nèi)得到有效緩解,并且各項炎癥因子水平明顯降低,炎性反應(yīng)減輕,有利于控制病情,促進(jìn)恢復(fù),提高患者生活質(zhì)量。
[Abstract]:Objective: to investigate the effect of ulinastatin intravenous drip combined with rhubarb decoction enema on severe pancreatitis patients and improve the level of inflammatory factors. From June 2009 to June 2013, 62 patients with severe pancreatitis were randomly selected. According to the time of admission, the patients were divided into observation group (n = 31) and control group (n = 31). The control group was treated with ulinastatin and the observation group was treated with ulinastatin combined with rhubarb decoction enema. To observe and record the clinical curative effect, clinical symptom regression time and TNF- 偽 of tumor necrosis factor 偽 (TNF- 偽) in the two groups. The changes of interleukin-6 (IL-6) and interleukin-8 (IL-8) were analyzed and compared. Results: after treatment, 15 cases were cured in the observation group, the total effective rate was 93.55%. The total effective rate of the control group was only 74.19, there was significant difference between the two groups (P 0.05). After treatment, the contents of TNF- 偽 IL-6 and IL-8 in the two groups were significantly lower than those before treatment. And the observation group is significantly lower than the control group, the two groups have statistical significance (P 0.05). After treatment, all patients serum amylase. Glutamate-pyruvic transaminase and white blood cell count were significantly lower than before treatment, and there was a significant difference between the observation group and the control group (P 0.05). The abdominal pain in the observation group was significantly lower than that in the control group. The recovery time of clinical symptoms such as exhaust and defecation was significantly lower than that of the control group. Conclusion: ulinastatin combined with rhubarb decoction enema is effective in the treatment of severe pancreatitis patients, and all clinical symptoms are effectively alleviated in a short time. The level of inflammatory factors and inflammatory response were significantly decreased, which was beneficial to control the disease, promote recovery and improve the quality of life of patients.
【作者單位】： 常山縣人民醫(yī)院;衢州市人民醫(yī)院;
【分類號】：R576
【正文快照】： lower than the control group's.Two groups were statistically significant(P0.05).Conclusion:Ulinastatin combinedwith rhubarb decoction enema has better clinical efficacy in patients with severe pancreatitis.The clinical symptoms canbe effectively allevia

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