【摘要】：目的：探討腫瘤M2型丙酮酸激酶(TuM2-PK)在鼻咽癌中的表達(dá),及其與鼻咽癌浸潤轉(zhuǎn)移和預(yù)后的關(guān)系。 方法：應(yīng)用免疫組化法檢測72例鼻咽癌和15例鼻咽炎性組織中TuM2-PK的表達(dá),并分析其與臨床病理學(xué)特征及預(yù)后的關(guān)系。 結(jié)果：1、TuM2-PK在鼻咽癌組織中表達(dá)率為51.4%(37／72),顯著高于鼻咽部炎性組織7%(1／15),兩組有顯著的統(tǒng)計學(xué)差異(P=0.001)。 2、TuM2-PK的表達(dá)與患者年齡、性別無明顯相關(guān)(P0.05),但TuM2-PK高表達(dá)患者較低表達(dá)患者具有更高的、淋巴結(jié)轉(zhuǎn)移率(P0.05)、遠(yuǎn)處轉(zhuǎn)移率(P=0.047)以及復(fù)發(fā)率(P=0.035)。 3、TuM2-PK高表達(dá)組5年生存率為37.8%,TuM2-PK低表達(dá)組5年生存率為68.6%,兩組有顯著的統(tǒng)計學(xué)差異(P0.05)。單因素分析顯示鼻咽癌患者5年生存率與T分期、淋巴結(jié)轉(zhuǎn)移情況、遠(yuǎn)處轉(zhuǎn)移、TNM分期、TuM2-PK的表達(dá)水平相關(guān)(P0.05)。多因素分析顯示淋巴結(jié)轉(zhuǎn)移情況、遠(yuǎn)處轉(zhuǎn)移、TNM分期及TuM2-PK的表達(dá)水平為鼻咽癌患者5年生存率的影響因素(P0.05)。 結(jié)論：鼻咽癌組織中TuM2-PK表達(dá)較鼻咽炎性組織中的表達(dá)明顯增強,并與鼻咽癌的T分期、淋巴結(jié)轉(zhuǎn)移、遠(yuǎn)處轉(zhuǎn)移以及復(fù)發(fā)密切相關(guān)。TuM2-PK可能作為判斷鼻咽癌轉(zhuǎn)移潛能和預(yù)后的輔助指標(biāo)。
[Abstract]:Aim: to investigate the expression of M 2 type pyruvate kinase (TuM2-PK) in nasopharyngeal carcinoma (NPC) and its relationship with invasion, metastasis and prognosis of NPC. Methods: immunohistochemical method was used to detect the expression of TuM2-PK in 72 cases of nasopharyngeal carcinoma and 15 cases of nasopharyngitis, and the relationship between the expression and clinicopathological features and prognosis was analyzed. Results: 1 the expression rate of TuM2 PK in nasopharyngeal carcinoma was 51.4% (37 / 72), which was significantly higher than that in nasopharyngeal inflammatory tissue (7%, 1 / 15). There was significant difference between the two groups (P < 0.001). 2. There was no significant correlation between the expression of TuM2-PK and the age and sex of the patients (P0.05), but the patients with high expression of TuM2-PK had higher lymph node metastasis rate than those with lower expression (P0.05). Distant metastasis rate (P < 0. 047) and recurrence rate (P = 0. 035). 3. The 5-year survival rate was 37.8% in the high-expression TuM2-PK group and 68.6% in the low-expression TuM2-PK group. There was significant difference between the two groups (P0.05). Univariate analysis showed that the 5-year survival rate was correlated with T stage, lymph node metastasis, distant metastasis, TNM stage and TuM2-PK expression (P0.05). Multivariate analysis showed that lymph node metastasis, distant metastasis, TNM stage and TuM2-PK expression were related to the 5-year survival rate of NPC patients (P0.05). Conclusion: the expression of TuM2-PK in nasopharyngeal carcinoma is significantly higher than that in inflammatory tissue of nasopharynx, and it is related to T stage and lymph node metastasis of nasopharyngeal carcinoma. TuM2-competition may be used as an auxiliary index to judge metastasis potential and prognosis of nasopharyngeal carcinoma (NPC).
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R739.63

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