發(fā)布時(shí)間：2019-03-20 18:52

【摘要】：目的探討鼻咽癌患者治療前外周血中血小板與淋巴細(xì)胞比(platelet-lymphocyte ratio,PLR)、中性粒細(xì)胞與淋巴細(xì)胞比(neutrophil-lymphocyte ratio,NLR)與總生存期(overall survival,OS)、無進(jìn)展生存期(progression-free survival,PFS)的相關(guān)性。方法回顧性分析西安交通大學(xué)第一附屬醫(yī)院和陜西省人民醫(yī)院2009年1月至2013年9月期間初治的91例鼻咽癌患者臨床資料,根據(jù)ROC曲線選取PLR和NLR的截?cái)嘀?將患者根據(jù)截?cái)嘀捣纸M,采用Kaplan-Meier法和Log rank檢驗(yàn)比較不同組患者的總生存率和無進(jìn)展生存率,應(yīng)用Cox比例風(fēng)險(xiǎn)模型進(jìn)行單因素和多因素分析。結(jié)果當(dāng)PLR=143.3、NLR=2.6時(shí),對(duì)患者的預(yù)后預(yù)測(cè)價(jià)值最高。Cox多因素分析發(fā)現(xiàn)PLR≥143.3(RR=2.491,95%CI=1.139~5.451,P=0.022)、NLR≥2.6(RR=2.186,95%CI=1.021~4.682,P=0.044)時(shí),患者的OS較短,而PLR≥143.3(RR=2.461,95%CI=1.242~4.874,P=0.01)時(shí),患者的PFS較差。結(jié)論治療前PLR和NLR可能是影響鼻咽癌患者預(yù)后的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the platelet to lymphocyte ratio (platelet-lymphocyte ratio,PLR), neutrophil to lymphocyte ratio (neutrophil-lymphocyte ratio,NLR), total survival time (overall survival,OS) and progression-free survival time (progression-free survival,) in peripheral blood of patients with nasopharyngeal carcinoma (NPC) before treatment. PFS). Methods the clinical data of 91 patients with nasopharyngeal carcinoma in the first affiliated Hospital of Xi'an Jiaotong University and people's Hospital of Shaanxi Province from January 2009 to September 2013 were retrospectively analyzed. According to the ROC curve, the cut-off values of PLR and NLR were selected. The patients were divided into two groups according to the cut-off value. Kaplan- Meier method and Log rank test were used to compare the overall survival rate and the progression-free survival rate in different groups. The Cox proportional hazard model was used for univariate and multivariate analysis. Results when PLR=143.3,NLR=2.6 was used, the prognostic value was the highest. Cox multivariate analysis showed that PLR 鈮，

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