【摘要】：目的觀察眼底激光、曲安奈德、復方樟柳堿聯(lián)合治療缺血型視網(wǎng)膜中央靜脈阻塞患者的療效及對視網(wǎng)膜血流的影響。設計前瞻性病例系列。研究對象北京同仁醫(yī)院缺血型視網(wǎng)膜中央靜脈阻塞患者90例(90眼)。方法所有患者均予以全視網(wǎng)膜激光光凝治療,按隨機數(shù)字表分為3組,每組各30眼,Ⅰ組予以曲安奈德40 mg眼周注射2次,Ⅱ組每日予復方樟柳堿注射液2 ml顳側皮下注射30天,Ⅲ組予以曲安奈德與復方樟柳堿注射液聯(lián)合治療。治療前、治療1個月時測定矯正視力,相干光斷層掃描(OCT)檢查黃斑中心厚度(CMT),彩色多普勒超聲檢測視網(wǎng)膜中央動脈的血流動力學指標。主要指標視網(wǎng)膜中央動脈的收縮期峰值血流速度(PSV)、舒張末期血流速度(EDV)、阻力指數(shù)(RI),視網(wǎng)膜中央靜脈的最大流速(Vmax)和最小流速(Vmin)。結果Ⅲ組治療后視網(wǎng)膜中央動脈的PSV和EDV均明顯高于Ⅰ組、Ⅱ組(均P0.05),RI明顯低于Ⅰ組、Ⅱ組(均P0.05),視網(wǎng)膜中央靜脈的Vmax和Vmin均明顯高于Ⅰ組、Ⅱ組(均P0.05)。Ⅲ組視力改善有效率明顯高于Ⅰ組、Ⅱ組(均P0.05),CMT明顯低于Ⅰ組、Ⅱ組(均P0.05)。結論眼底激光、曲安奈德、復方樟柳堿聯(lián)合治療能有效改善缺血型視網(wǎng)膜中央靜脈阻塞患者中央血管的血流動力學,優(yōu)化治療效果。
[Abstract]:Objective to observe the effect of fundus laser, triamcinolone acetonide and compound anisodine on retinal blood flow in patients with ischemic central retinal vein occlusion. Design prospective case series. Participants 90 patients (90 eyes) with ischemic central retinal vein occlusion in Tongren Hospital of Beijing. Methods all the patients were treated with total retinal laser photocoagulation. They were randomly divided into 3 groups with 30 eyes in each group. Group I was given triamcinolone acetonide 40 mg intraocular injection twice. Group 鈪，

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