【摘要】：目的初步探討血清25-羥維生素D[25(OH)D]在良性陣發(fā)性位置性眩暈(BPPV)發(fā)生、復(fù)發(fā)中的作用。方法納入2013年1月至2014年12月在上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院神經(jīng)內(nèi)科診治的部分BPPV患者,根據(jù)1年隨訪結(jié)果,分為BPPV未復(fù)發(fā)組(n=207)及復(fù)發(fā)組(n=42),并將同期收治的其他眩暈病患者作為對照(n=43),比較3組患者血清25(OH)D水平的差異,并分析影響所有受試者血清25(OH)D水平的獨立相關(guān)因素。結(jié)果與眩暈對照組相比,BPPV未復(fù)發(fā)組、復(fù)發(fā)組血清25(OH)D水平均下降(P均0.01),而復(fù)發(fā)組與未復(fù)發(fā)組血清25(OH)D水平差異無統(tǒng)計學(xué)意義。BPPV復(fù)發(fā)組女性比例較其余兩組略增高,但差異無統(tǒng)計學(xué)意義(P=0.073)。所有入組患者中女性血清25(OH)D水平低于男性[(18.7±7.5)ng/mL vs(21.7±8.3)ng/mL,P=0.002]。多因素逐層線性回歸分析顯示女性(β=-2.6,P=0.005)、BPPV(β=-5.5,P0.001)是患者血清25(OH)D水平的獨立影響因素。結(jié)論人血清25(OH)D水平存在性別差異,BPPV患者25(OH)D水平下降。
[Abstract]:Objective to investigate the role of serum 25 hydroxyvitamin D [25 (OH) D] in the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV). Methods from January 2013 to December 2014, some BPPV patients treated in the Department of Neurology, Ninth people's Hospital, School of Medicine, Shanghai Jiaotong University, were included. According to the results of 1-year follow-up, the patients were divided into two groups: no recurrent BPPV group (nx207) and relapsed group (NX42). Other vertigo patients treated in the same period were used as control group (nnf43) to compare the difference of serum 25 (OH) D level among the three groups, and to analyze the independent factors affecting the serum 25 (OH) D level of all the subjects. Results compared with the vertigo control group, the serum 25 (OH) D level in the BPPV group and the relapsing group decreased significantly (P 0.01). However, there was no significant difference in serum 25 (OH) D level between relapsed group and non-recurrent group. The proportion of female in recurrent BPPV group was slightly higher than that in the other two groups, but the difference was not statistically significant (P0. 073). The serum 25 (OH) D level in women was lower than that in males [(18.7 鹵7.5) ng/mL vs (21.7 鹵8.3) ng/mL,P=0.002]. Multivariate linear regression analysis showed that women (尾 = -2.6), BPPV (尾 = -5.5), BPPV (P 0.001) were independent factors of serum 25 (OH) D level. Conclusion there is a gender difference in serum 25 (OH) D level, and 25 (OH) D level in BPPV patients is decreased.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院神經(jīng)內(nèi)科;
【基金】：上海交通大學(xué)醫(yī)學(xué)院(理學(xué))基金(14XJ10063)~~
【分類號】：R764

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