【摘要】：耳蝸基底膜振動(dòng)對(duì)聲音頻率和強(qiáng)度的分辨能力具有重要作用。以往的基底膜振動(dòng)模型沒有考慮外毛細(xì)胞主動(dòng)運(yùn)動(dòng)(即電致運(yùn)動(dòng))的不同速度(即延時(shí)效應(yīng))對(duì)基底膜振動(dòng)的影響,無法全面闡述基底膜振動(dòng)過程中外毛細(xì)胞的主動(dòng)作用。為此我們介紹了一個(gè)新的模型,該模型考慮了外毛細(xì)胞電致運(yùn)動(dòng)的延時(shí)效應(yīng)。仿真結(jié)果顯示,新的模型完全符合外毛細(xì)胞電致運(yùn)動(dòng)的生理特征,從一個(gè)新的角度詮釋了外毛細(xì)胞電致運(yùn)動(dòng)對(duì)基底膜振動(dòng)作用的貢獻(xiàn)。 膜蛋白Prestin是外毛細(xì)胞電致運(yùn)動(dòng)的關(guān)鍵元件,對(duì)哺乳動(dòng)物耳蝸放大器和頻率選擇性至關(guān)重要。Prestin作用的發(fā)揮受到細(xì)胞內(nèi)氯離子和蛋白質(zhì)表面電荷的影響,其中氯離子的影響是決定性的。為了研究Prestin轉(zhuǎn)移電荷(即氯離子和蛋白質(zhì)表面電荷)在受到外加電場(chǎng)作用時(shí)對(duì)頻率和電壓的依賴性質(zhì),本文介紹一個(gè)新的電擴(kuò)散模型,該模型用Fokker-Plank方程描述Prestin轉(zhuǎn)移電荷的動(dòng)力學(xué)性質(zhì)。模型分析的結(jié)果與實(shí)驗(yàn)觀察是一致的,有助于對(duì)Prestin的結(jié)構(gòu)和功能的進(jìn)一步分析。
[Abstract]:The vibration of the basal membrane of cochlea plays an important role in the resolution of sound frequency and intensity. Previous models of basement membrane vibration did not take into account the effects of different velocities of outer hair cell active motion (i.e. electroinduced motion) on the vibration of basement membrane, and could not fully explain the active action of outer and outer hair cells in the process of basement membrane vibration. For this reason, we introduce a new model, which takes into account the delay effect of external hair cell electromotion. The simulation results show that the new model fully accords with the physiological characteristics of external hair cell electromotion, and explains the contribution of external hair cell electromotion to the vibration of basement membrane from a new point of view. Membrane protein Prestin is a key element in electroporation of outer hair cells, which plays an important role in mammalian cochlear amplifier and frequency selectivity. The role of Prestin is affected by intracellular chloride ion and surface charge of protein. The influence of chloride ion is decisive. In order to study the dependence of Prestin transfer charge (that is, chloride ion and protein surface charge) on frequency and voltage under the action of external electric field, a new electric diffusion model is introduced in this paper. The Fokker-Plank equation is used to describe the kinetic properties of Prestin transfer charge. The results of the model analysis are consistent with the experimental observation, which is helpful to the further analysis of the structure and function of Prestin.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R764

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本文編號(hào)：2346421