酪酸梭菌二聯(lián)活菌膠囊輔助治療變應(yīng)性鼻炎的療效觀察
發(fā)布時(shí)間：2018-11-20 06:42
【摘要】：目的:通過對(duì)比應(yīng)用酪酸梭菌二聯(lián)活菌膠囊(又名常樂康)等藥物前后變應(yīng)性鼻炎患者血清中IL-10、TGF-β1及四分法、視覺模擬量表、鼻結(jié)膜炎生活質(zhì)量調(diào)查問卷評(píng)分的變化來觀察常樂康輔助治療變應(yīng)性鼻炎的的療效。方法:1.根據(jù)納入標(biāo)準(zhǔn)、排除標(biāo)準(zhǔn)、退出標(biāo)準(zhǔn)最終收集到符合條件的季節(jié)性中-重度變應(yīng)性鼻炎患者研究組20例,對(duì)照組20例。研究組給予常樂康、枸地氯雷他定片、糠酸莫米松鼻噴劑治療2周后繼續(xù)給予常樂康維持治療6周,而停用其他兩種藥物。對(duì)照組給予枸地氯雷他定片+糠酸莫米松鼻噴劑治療2周后退出臨床實(shí)驗(yàn)。2.收集研究組和對(duì)照組患者在治療前、治療2周后、治療結(jié)束后血清并通過四分法、視覺模擬量表、鼻結(jié)膜炎生活質(zhì)量調(diào)查問卷(RQLQ)進(jìn)行評(píng)分。同時(shí)收集健康成人血清10份作為正常組。最后采用酶聯(lián)免疫吸附試驗(yàn)檢測(cè)三組中每位受試者每個(gè)階段血清中IL-10、TGF-β1水平。3.統(tǒng)計(jì)數(shù)據(jù):(1)研究組患者在治療前、治療2周后、治療結(jié)束后IL-10、TGF-β1、癥狀評(píng)分、RQLQ總評(píng)分的變化有無統(tǒng)計(jì)學(xué)意義;(2)研究組和對(duì)照組在治療2周后IL-10、TGF-β1、癥狀評(píng)分、RQLQ總評(píng)分有無差別;(3)分析IL-10水平、TGF-β1水平分別與癥狀評(píng)分、RQLQ總評(píng)分的相關(guān)性。結(jié)果:1.治療前正常組、研究組、對(duì)照組血清TGF-β1和IL-10水平總體差異有統(tǒng)計(jì)學(xué)意義(P0.001),且研究組、對(duì)照組均顯著低于正常組。2.隨著治療時(shí)間的增加,研究組患者血清中IL-10、TGF-β1水平逐漸升高(治療8周后治療2周后治療前),四分法眼部癥狀評(píng)分、VAS眼部癥狀評(píng)分、RQLQ總分逐漸降低(治療8周后治療2周后治療前)。3.對(duì)照組患者治療2周后血清IL-10、TGF-β1均高于治療前(P0.001),四分法鼻部癥狀、四分法眼部癥狀,VAS鼻部癥狀、VAS眼部癥狀,RQLQ總評(píng)分均低于治療前(P0.001)。4.治療2周后研究組患者血清IL-10高于對(duì)照組(P0.001),但兩組間TGF-β1、癥狀及生活質(zhì)量評(píng)分均無統(tǒng)計(jì)學(xué)差異(P0.05)5.治療前AR患者血清IL-10、TGF-β1與四分法鼻部癥狀評(píng)分、四分法眼部癥狀評(píng)分、VAS鼻部癥狀評(píng)分、VAS眼部癥狀評(píng)分、RQLQ總分之間均無線性相關(guān)關(guān)系(P0.05)。結(jié)論:1.AR患者血清IL-10、TGF-β1水平低于正常組提示IL-10、TGF-β1可能參與了AR的發(fā)病。2.酪酸梭菌二聯(lián)活菌膠囊可能對(duì)研究組AR患者血清IL-10、TGF-β1的產(chǎn)生起促進(jìn)作用。3.枸地氯雷他定和糠酸莫米松鼻噴劑聯(lián)合治療可能對(duì)AR患者血清IL-10、TGF-β1的產(chǎn)生起促進(jìn)作用。4.AR患者在枸地氯雷他定和糠酸莫米松鼻噴劑治療的基礎(chǔ)上加用酪酸梭菌二聯(lián)活菌膠囊可能比常規(guī)的二者聯(lián)合治療更能促進(jìn)血清IL-10的產(chǎn)生,但在癥狀及生活質(zhì)量方面沒有更明顯的改善。5.酪酸梭菌二聯(lián)活菌膠囊可能對(duì)AR患者眼部癥狀、總生活質(zhì)量的改善有一定的作用。6.AR患者治療前血清IL-10、TGF-β1水平可能與其癥狀、生活質(zhì)量關(guān)聯(lián)性較小,暫不能用血清IL-10、TGF-β1水平的高低來評(píng)估AR的病情嚴(yán)重程度。
[Abstract]:Objective: to compare the application of IL-10,TGF- 尾 1 and quaternion in the serum of patients with allergic rhinitis before and after administration of Clostridium caseinate biplex capsule (also known as Changlekang), and to evaluate the visual analogue scale. To observe the efficacy of Changle Kang in the treatment of allergic rhinitis. Methods: 1. According to the inclusion criteria, exclusion criteria and exit criteria, 20 cases of seasonal moderate to severe allergic rhinitis were collected in the study group and 20 cases in the control group. The study group was treated with Changlekang, loratadine citrate and momethasone furoate nasal spray for 6 weeks, while the other two drugs were stopped. The control group was treated with momethasone furoate for 2 weeks and withdrew from the clinical trial. 2. The patients in the study group and the control group were assessed by the four points visual analogue scale and the quality of life questionnaire (RQLQ) before and after 2 weeks of treatment. At the same time, 10 healthy adult serum samples were collected as normal group. Finally, the serum IL-10,TGF- 尾 1 levels in each of the three groups were measured by enzyme linked immunosorbent assay (Elisa). Statistical data: (1) before treatment, 2 weeks after treatment, and after treatment, the changes of IL-10,TGF- 尾 1, symptom score and total RQLQ score were statistically significant. (2) there were differences in IL-10,TGF- 尾 1, symptom score and total RQLQ score between study group and control group 2 weeks after treatment. (3) the correlation between IL-10 level, TGF- 尾 1 level and symptom score and RQLQ total score were analyzed. The result is 1: 1. The levels of serum TGF- 尾 1 and IL-10 in normal group, study group and control group were significantly different before treatment (P0.001), and the levels of serum TGF- 尾 1 and IL-10 in study group and control group were significantly lower than those in normal group. With the increase of treatment time, the serum levels of IL-10,TGF- 尾 1 in the study group increased gradually (8 weeks after treatment and 2 weeks after treatment before treatment), the four-point ocular symptom score, the VAS ocular symptom score, The total score of RQLQ gradually decreased (8 weeks after treatment 2 weeks before treatment). 3. After 2 weeks of treatment, the serum IL-10,TGF- 尾 1 levels in the control group were significantly higher than those before treatment (P0.001). The scores of nasal symptoms, eye symptoms, VAS nasal symptoms, VAS ocular symptoms and RQLQ scores were significantly lower in the control group than before treatment (P0.001). After 2 weeks of treatment, the serum IL-10 of the patients in the study group was higher than that of the control group (P0.001), but there was no significant difference in TGF- 尾 1, symptom and quality of life score between the two groups (P0.05). Before treatment, there was no linear correlation between serum IL-10,TGF- 尾 1 and four score nasal symptom score, four score eye symptom score, VAS nasal symptom score, VAS ocular symptom score and total RQLQ score (P0.05). Conclusion: the level of serum IL-10,TGF- 尾 1 in 1.AR patients is lower than that in normal controls, suggesting that IL-10,TGF- 尾 1 may be involved in the pathogenesis of AR. 2. 2. Clostridium caseate combined with living bacillus capsule may promote the production of serum IL-10,TGF- 尾 1 in AR patients in study group. 3. 3. Combined treatment of citric loratadine and momethasone furoate nasal spray may be used in the treatment of serum IL-10, in patients with AR The effect of TGF- 尾 _ 1 on the production of TGF- 尾 _ 1.The combination of clostridium butyrate and momethasone furoate nasal spray in patients with 4.AR may promote the production of serum IL-10 more than the conventional combination therapy of Clostridium caseate and Clostridium caseate. But there was no more significant improvement in symptoms and quality of life. The capsule of Clostridium caseinate combined with living bacteria may have a certain effect on the improvement of ocular symptoms and total quality of life in patients with AR. The serum IL-10,TGF- 尾 1 level may be related to the symptoms of patients with 6.AR before treatment, and the quality of life is not related to the patients' quality of life. Serum levels of IL-10,TGF- 尾 1 could not be used to assess the severity of AR.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R765.21
本文編號(hào)：2344102
[Abstract]:Objective: to compare the application of IL-10,TGF- 尾 1 and quaternion in the serum of patients with allergic rhinitis before and after administration of Clostridium caseinate biplex capsule (also known as Changlekang), and to evaluate the visual analogue scale. To observe the efficacy of Changle Kang in the treatment of allergic rhinitis. Methods: 1. According to the inclusion criteria, exclusion criteria and exit criteria, 20 cases of seasonal moderate to severe allergic rhinitis were collected in the study group and 20 cases in the control group. The study group was treated with Changlekang, loratadine citrate and momethasone furoate nasal spray for 6 weeks, while the other two drugs were stopped. The control group was treated with momethasone furoate for 2 weeks and withdrew from the clinical trial. 2. The patients in the study group and the control group were assessed by the four points visual analogue scale and the quality of life questionnaire (RQLQ) before and after 2 weeks of treatment. At the same time, 10 healthy adult serum samples were collected as normal group. Finally, the serum IL-10,TGF- 尾 1 levels in each of the three groups were measured by enzyme linked immunosorbent assay (Elisa). Statistical data: (1) before treatment, 2 weeks after treatment, and after treatment, the changes of IL-10,TGF- 尾 1, symptom score and total RQLQ score were statistically significant. (2) there were differences in IL-10,TGF- 尾 1, symptom score and total RQLQ score between study group and control group 2 weeks after treatment. (3) the correlation between IL-10 level, TGF- 尾 1 level and symptom score and RQLQ total score were analyzed. The result is 1: 1. The levels of serum TGF- 尾 1 and IL-10 in normal group, study group and control group were significantly different before treatment (P0.001), and the levels of serum TGF- 尾 1 and IL-10 in study group and control group were significantly lower than those in normal group. With the increase of treatment time, the serum levels of IL-10,TGF- 尾 1 in the study group increased gradually (8 weeks after treatment and 2 weeks after treatment before treatment), the four-point ocular symptom score, the VAS ocular symptom score, The total score of RQLQ gradually decreased (8 weeks after treatment 2 weeks before treatment). 3. After 2 weeks of treatment, the serum IL-10,TGF- 尾 1 levels in the control group were significantly higher than those before treatment (P0.001). The scores of nasal symptoms, eye symptoms, VAS nasal symptoms, VAS ocular symptoms and RQLQ scores were significantly lower in the control group than before treatment (P0.001). After 2 weeks of treatment, the serum IL-10 of the patients in the study group was higher than that of the control group (P0.001), but there was no significant difference in TGF- 尾 1, symptom and quality of life score between the two groups (P0.05). Before treatment, there was no linear correlation between serum IL-10,TGF- 尾 1 and four score nasal symptom score, four score eye symptom score, VAS nasal symptom score, VAS ocular symptom score and total RQLQ score (P0.05). Conclusion: the level of serum IL-10,TGF- 尾 1 in 1.AR patients is lower than that in normal controls, suggesting that IL-10,TGF- 尾 1 may be involved in the pathogenesis of AR. 2. 2. Clostridium caseate combined with living bacillus capsule may promote the production of serum IL-10,TGF- 尾 1 in AR patients in study group. 3. 3. Combined treatment of citric loratadine and momethasone furoate nasal spray may be used in the treatment of serum IL-10, in patients with AR The effect of TGF- 尾 _ 1 on the production of TGF- 尾 _ 1.The combination of clostridium butyrate and momethasone furoate nasal spray in patients with 4.AR may promote the production of serum IL-10 more than the conventional combination therapy of Clostridium caseate and Clostridium caseate. But there was no more significant improvement in symptoms and quality of life. The capsule of Clostridium caseinate combined with living bacteria may have a certain effect on the improvement of ocular symptoms and total quality of life in patients with AR. The serum IL-10,TGF- 尾 1 level may be related to the symptoms of patients with 6.AR before treatment, and the quality of life is not related to the patients' quality of life. Serum levels of IL-10,TGF- 尾 1 could not be used to assess the severity of AR.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R765.21
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