【摘要】：目的探討血清25-羥基維生素D[25(OH)D]和干眼(dry eye,DE)發(fā)生的關(guān)系。方法本研究共納入58例DE患者(DE組,n=58)及30例健康對照者(對照組,n=30),采用酶聯(lián)免疫吸附法(ELISA)檢測血清25(OH)D含量,分析血清25(OH)D與眼表疾病指數(shù)(ocular surface disease index,OSDI)量表、淚膜破裂時間(break-up time,BUT)及淚液分泌試驗(Schirmer I test,SIT)的相關(guān)性。結(jié)果 DE組SIT為(7.47±3.01)mm/5 min,較對照組(14.56±3.48)mm/5min明顯下降(t=9.926,P=0.000),DE組BUT為(6.03±2.14)s,明顯低于對照組(12.05±3.27)s(t=10.392,P=0.000),而DE組OSDI評分(36.19±17.23)分顯著高于對照組(16.67±5.01)分(t=6.059,P=0.000)。DE組血清25(OH)D水平(18.42±7.57)ng·mL~(-1)明顯低于對照組(32.49±12.85)ng·mL~(-1)(t=6.467,P=0.000)。血清25(OH)D缺乏在DE組中更常見(χ~2=30.995,P=0.000)。Pearson相關(guān)分析顯示,血清25(OH)D水平與SIT呈正相關(guān)(r=0.652,P=0.000),與BUT(r=-0.531,P=0.000)、OSDI(r=-0.480,P=0.000)均呈負(fù)相關(guān)。結(jié)論低血清25(OH)D水平可能與DE發(fā)生顯著相關(guān)。
[Abstract]:Objective to investigate the relationship between serum 25-hydroxyvitamin D [25 (OH) D] and dry eye (dry eye,DE). Methods A total of 58 patients with DE (DE group, nun58) and 30 healthy controls (control group, nun30) were enrolled in this study. The serum 25 (OH) D levels were detected by Elisa (ELISA). The correlation between serum 25 (OH) D and ocular surface disease index (ocular surface disease index,OSDI), tear film rupture time (break-up time,BUT) and tear secretion test (Schirmer I test,SIT) was analyzed. Results the SIT of DE group was (7.47 鹵3.01) mm/5 min, significantly lower than that of control group (14.56 鹵3.48) mm/5min (t = 9.926 ~ 0.000 BUT = (6.03 鹵2.14) s). The OSDI score of DE group (36.19 鹵17.23) was significantly higher than that of control group (16.67 鹵5.01) (t = 6.059). The serum level of 25 (OH) D (18.42 鹵7.57) ng mL~ (-1) in 0.000). DE group was significantly lower than that in the control group (32.49 鹵12.85 ng mL~ (-1). Serum 25 (OH) D deficiency was more common in DE group (蠂 ~ 2 = 30.995P ~ + 0.000). Pearson correlation analysis showed that the serum 25 (OH) D level was positively correlated with SIT (r = 0.652) and BUT (r = -0.531P ~ (0.000). OSDI (r-0.480) was negatively correlated. Conclusion low serum 25 (OH) D level may be significantly correlated with DE.
【作者單位】： 首都醫(yī)科大學(xué)密云教學(xué)醫(yī)院眼科;
【分類號】：R777.34

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