【摘要】：目的:本實(shí)驗(yàn)擬研究錳超氧化物歧化酶(SOD2)變異在原發(fā)性開角型青光眼(POAG)中的作用。方法:以750例散發(fā)青光眼患者和1 500例正常對(duì)照者,對(duì)rs6917589、rs2842980、rs5746136、rs4880的SOD2單核苷酸多態(tài)性(SNP)位點(diǎn)用SNa Pshot法進(jìn)行基因分型。采用χ2檢驗(yàn)對(duì)等位基因頻率進(jìn)行分析。結(jié)果:等位基因關(guān)聯(lián)分析表明,rs6917589和rs5746136與POAG有相關(guān)性(P=0.023和P=0.026)。rs2842980和rs4880與POAG無(wú)相關(guān)性(P=0.064和P=0.703)。由這4個(gè)SNP組成的單倍體型ATGT有POAG的趨勢(shì)(P=0.003 2)。結(jié)論:我們的結(jié)果顯示SOD2與POAG的發(fā)生存在相關(guān)性,表明SOD2可能在POAG發(fā)展過(guò)程中發(fā)揮重要作用。
[Abstract]:Objective: to study the role of manganese superoxide dismutase (SOD2) variation in (POAG) of primary open angle glaucoma. Methods: in 750 sporadic glaucoma patients and 1 500 normal controls, the SOD2 single nucleotide polymorphism (SNP) (SNP) loci of rs6917589,rs2842980,rs5746136,rs4880 were genotyped by SNa Pshot. The allele frequency was analyzed by 蠂 2 test. Results: allelic association analysis showed that rs6917589 and rs5746136 were correlated with POAG (P0. 023 and P0. 026), but rs2842980 and rs4880 were not correlated with POAG (P0. 064 and P0. 703). The haploid ATGT composed of these four SNP has the tendency of POAG (P0. 0032). Conclusion: our results show that there is a correlation between SOD2 and POAG, suggesting that SOD2 may play an important role in the development of POAG.
【作者單位】： 四川省醫(yī)學(xué)科學(xué)院·四川省人民醫(yī)院檢驗(yàn)科;
【分類號(hào)】：R775.2
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本文編號(hào)：2316890