【摘要】：目的:觀察迎香穴穴位注射聯(lián)合口服抗組胺藥治療變應(yīng)性鼻炎的臨床療效和安全性。方法:選取我院耳鼻咽喉科門診收治的變應(yīng)性鼻炎患者80例(就診時間為2016年1月至2016年12月期間),隨機將80例患者分為觀察組和對照組。觀察組采用迎香穴穴位注射聯(lián)合口服抗組胺藥的方法,對照組采用口服抗組胺藥。穴位注射治療每周1次,口服抗組胺藥物為每日1次,以4周為一個療程。分別記錄患者治療前、治療4周后、治療結(jié)束后3個月的臨床癥狀、體征、鼻炎相關(guān)生活質(zhì)量情況,用以評估近、遠期臨床療效。采用統(tǒng)計學(xué)軟件SPSS21.0進行統(tǒng)計學(xué)分析,規(guī)定當(dāng)P0.05時,則表示差異有統(tǒng)計學(xué)意義性。對兩組患者性別、年齡、病程、病情等一般資料進行分析比較,經(jīng)統(tǒng)計學(xué)分析,結(jié)果顯示差異均無統(tǒng)計學(xué)意義,說明組間資料具有可比性。結(jié)果:1、臨床療效:(1)治療4周后,觀察組總有效率92.5%,對照組總有效率85%,經(jīng)檢驗兩組療效差異有統(tǒng)計學(xué)意義(Z=-4.656,P0.001)。(2)治療結(jié)束后3個月,觀察組總有效率80%,對照組總有效率55%,經(jīng)檢驗兩組療效差異有統(tǒng)計學(xué)意義(Z=-4.444,P0.001)。2、癥狀、體征改善:(1)治療4周后,組內(nèi)比較:觀察組與對照組對癥狀、體征的改善在治療前后均有差異,且差異有統(tǒng)計學(xué)意義(觀察組:t=16.790,P0.001;對照組:t=16.292,P0.001);組間比較:觀察組在改善患者癥狀上優(yōu)于對照組,且組間差異有統(tǒng)計學(xué)意義(t=-4.51,P0.001)。(2)治療結(jié)束后3個月:組內(nèi)比較:觀察組與對照組對癥狀、體征的改善在治療前后均有差異,且差異有統(tǒng)計學(xué)意義(t=17.265,P0.001;t=9.531,P0.001);組間比較:觀察組在改善患者癥狀、體征上優(yōu)于對照組,且組間差異有統(tǒng)計學(xué)意義(t=-4.112,P=0.007);3、鼻炎相關(guān)生活質(zhì)量評分改善:(1)治療4周后,組內(nèi)比較:觀察組與對照組對生活質(zhì)量評分的改善在治療前后均有差異,且差異有統(tǒng)計學(xué)意義(t=12.549,P0.001;t=-10,P0.001);組間比較:觀察組在改善患者鼻炎生活質(zhì)量分上優(yōu)于對照組,組間差異有統(tǒng)計學(xué)意義(t=4.288,P0.001)。(2)治療結(jié)束后3個月:組內(nèi)比較:治療前后觀察組和對照組組內(nèi)鼻炎相關(guān)生活質(zhì)量分改善情況均有統(tǒng)計學(xué)差異(t=-5.976,P0.001;t=-3.798,P0.001),組間比較:觀察組在改善患者鼻炎生活質(zhì)量分上優(yōu)于對照組,組間差異有統(tǒng)計學(xué)意義(t=-4.51,P=0.007)。結(jié)論:迎香穴穴位注射聯(lián)合口服抗組胺藥和單純口服抗組胺藥治療變應(yīng)性鼻炎均可獲得一定的近遠期臨床療效,穴位注射聯(lián)合口服抗組胺藥的臨床療效優(yōu)于單純口服抗組胺藥。
[Abstract]:Objective: to observe the clinical efficacy and safety of Yingxiang acupoint injection combined with oral antihistamine in the treatment of allergic rhinitis. Methods: 80 patients with allergic rhinitis (from January 2016 to December 2016) were randomly divided into observation group and control group. The observation group was treated with Yingxiang acupoint injection combined with oral antihistamine, and the control group with oral antihistamine. Acupoint injection was given once a week and oral antihistamine was given once a day for 4 weeks as a course of treatment. The clinical symptoms, signs and quality of life related to rhinitis were recorded before treatment, 4 weeks after treatment and 3 months after treatment. The statistical software SPSS21.0 was used for statistical analysis. When P05 was specified, the difference was statistically significant. The data of sex, age, course of disease and disease were analyzed and compared between the two groups. The results showed that there was no statistical significance between the two groups, which indicated that the data between the two groups were comparable. Results: 1. Clinical efficacy: (1) after 4 weeks of treatment, the total effective rate of the observation group was 92.5 and the total effective rate of the control group was 85. Three months after treatment, the total effective rate of the observation group was 80 and that of the control group was 55. The difference between the two groups was statistically significant (P 0.001). The improvement of physical signs: (1) after 4 weeks of treatment, there were significant differences in the improvement of symptoms and signs between the observation group and the control group after 4 weeks of treatment (observation group: t = 16.790, P 0.001); In the control group: taut 16.292 (P0.001); Comparison between groups: the observation group was superior to the control group in improving the symptoms of the patients, and the difference between the two groups was statistically significant (t _ (-4.51) P _ (0.001). (_ 2) 3 months after the end of the treatment: comparison of the symptoms between the observation group and the control group, there was no significant difference between the observation group and the control group. The improvement of physical signs was different before and after treatment, and the difference was statistically significant (t = 17.265, P 0.001). Comparison between groups: the observation group was superior to the control group in improving the symptoms and signs of the patients, and the difference between the two groups was statistically significant (t = -4.112, P < 0. 007). 3, rhinitis related quality of life score improvement: (1) after 4 weeks of treatment, there were significant differences between the observation group and the control group in the improvement of the quality of life score before and after treatment, and the difference was statistically significant (t = 12.549, P 0.001); T _ (10) (P _ (0.001); Comparison between groups: the quality of life in the observation group was better than that in the control group in improving the quality of life of the patients with rhinitis, and the difference between the two groups was statistically significant (t = 4.288, P < 0.05). P0. 001). (2) 3 months after the end of treatment: intragroup comparison: before and after treatment, the improvement of quality of life related to rhinitis in the observation group and the control group was significantly different (t = 5.976, P 0.001); Comparison between groups: the quality of life in the observation group was better than that in the control group in improving the quality of life of the patients with rhinitis, and the difference between the two groups was statistically significant (t = -4.51, P0. 007). Conclusion: Yingxiang acupoint injection combined with oral antihistamine and oral antihistamine alone can obtain some short-term and long-term clinical efficacy in the treatment of allergic rhinitis. The clinical efficacy of acupoint injection combined with oral antihistamine is better than that of oral antihistamine alone.
【學(xué)位授予單位】：西南醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R765.21

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