【摘要】：目的探討絕經(jīng)期女性阻塞性睡眠呼吸暫停綜合征(OSAS)的臨床特征及其相關(guān)風(fēng)險因素。方法選取絕經(jīng)期早期OSAS受試者87例、絕經(jīng)期晚期OSAS受試者86例。測量受試者頸圍、腹圍;應(yīng)用Epworth嗜睡量表評價受試者嗜睡程度;多導(dǎo)睡眠監(jiān)測法檢測受試者睡眠呼吸暫停指數(shù)(AHI),低通氣占AHI的比例,夜間最低血氧飽和度(SpO_2),最長呼吸暫停時間;晨起檢測受試者收縮壓和舒張壓。進一步在兩組受試者中進行頸圍、腹圍以及收縮壓,舒張壓與AHI的相關(guān)分析。結(jié)果與絕經(jīng)期早期組相比,絕經(jīng)期晚期組表現(xiàn)出嗜睡程度更高以及更高的AHI;低通氣所占AHI比例在絕經(jīng)早期組意義明顯高于絕經(jīng)晚期組(P0.001),夜間最低Sp O2在絕經(jīng)晚期組較絕經(jīng)早期組表現(xiàn)為更低(P0.05),最長呼吸暫停時間在兩組無統(tǒng)計學(xué)差異(P0.05)。腹圍和收縮壓絕經(jīng)晚期組高于絕經(jīng)早期組(P0.05);相關(guān)分析結(jié)果顯示,兩組患者腹圍與AHI呈正相關(guān)(r=0.914,P0.001);AHI與收縮壓呈正相關(guān)(r=0.822,P0.001)。結(jié)論絕經(jīng)期女性O(shè)SAS嚴重程度隨絕經(jīng)期延長逐漸加重;肥胖是絕經(jīng)期女性O(shè)SAS不可忽視的危險因素,減體重或為預(yù)防和治療絕經(jīng)期女性O(shè)SAS的重要措施;絕經(jīng)期女性O(shè)SAS嚴重度增高可提高高血壓的風(fēng)險。
[Abstract]:Objective to investigate the clinical features and risk factors of obstructive sleep apnea syndrome (OSAS) in menopausal women. Methods 87 cases of early menopausal OSAS and 86 cases of late menopausal OSAS were selected. The neck circumference and abdominal circumference were measured and the degree of somnolence was evaluated by Epworth somnolence scale. Polysomnography was used to detect the proportion of sleep apnea index (AHI),) hypopnea to AHI, the lowest nocturnal oxygen saturation (SpO_2), the longest apnea time, and the systolic and diastolic blood pressure (DBP). The relationship between neck circumference, abdominal circumference, systolic blood pressure, diastolic blood pressure and AHI was further analyzed in both groups. Results compared with the early menopausal group, the late menopausal group showed higher somnolence and higher AHI;. The percentage of AHI in the early menopausal group was significantly higher than that in the late menopausal group (P0.001), and the lowest Sp O2 at night was lower in the late menopausal group than in the early menopausal group (P0.05). There was no significant difference in the longest apnea time between the two groups (P0.05). The abdominal circumference and systolic blood pressure in late menopausal group were higher than those in early menopausal group (P0.05), and the results of correlation analysis showed that the abdominal circumference was positively correlated with AHI (r = 0.914) P0.001); AHI was positively correlated with systolic blood pressure (r ~ (0.822) P ~ (0.001). Conclusion the severity of OSAS in menopausal women increases gradually with the prolongation of menopausal period, obesity is a risk factor that can not be ignored in menopausal women with OSAS, and weight loss is an important measure to prevent and treat menopausal women with OSAS. A severe increase in OSAS may increase the risk of hypertension in menopausal women.
【作者單位】： 吉林大學(xué)第一醫(yī)院呼吸內(nèi)科;吉林省人民醫(yī)院神經(jīng)內(nèi)科;
【基金】：國家自然科學(xué)基金資助項目(81300062) 吉林省衛(wèi)生廳科技基金資助項目(2013Z007)
【分類號】：R766

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