【摘要】：目的應(yīng)用血氧水平依賴的功能磁共振(Blood oxygen level dependent-function magnetic resonance imaging, BOLD-fMRI)技術(shù),研究屈光性弱視患兒立體視皮層功能特點,對比比較屈光不正性弱視與屈光參差性弱視之間腦皮層的激活差異及特點。 方法初診弱視患兒11例,其中屈光不正性患兒5例(2男3女,平均8±1.5歲),屈光參差性患兒6例(4男2女,平均9±2歲)。所有被試均為遠(yuǎn)視性弱視,中心凹注視；均為右利手；所有被試無局部及全身特殊病史。試驗前充分矯正屈光不正；規(guī)范化弱視訓(xùn)練后1周及4周時復(fù)查fMRI。 通過E-Prime2.0軟件編寫視覺刺激任務(wù)程序,刺激模式為對比度接近80%的紅藍(lán)立體圖像,以SIEMENS MAGNETOM Verio3.0T磁共振掃描系統(tǒng),分別采集弱視兒童BOLD-fMRI數(shù)據(jù)。采用SPM8軟件包對圖像進行處理及分析。比較1.不同時期弱視兒童腦皮層激活差異；2.不同時期屈光不正性弱視組與屈光參差性弱視組間視皮層激活強度及范圍的差異變化特點。 結(jié)果1.當(dāng)設(shè)定P值為0.001,激活范圍閾值為10個體素時,屈光性弱視患兒雙眼的興奮區(qū)域為以枕葉為中心的視覺皮層,其中以BA18/19/17區(qū)皮層激活程度最顯著；隨訓(xùn)練時間延長,弱視組立體視皮層功能活動范圍及活動強度均有所增強。2.當(dāng)設(shè)定P值為0.05,激活范圍閾值為10個體素時進行組間比較時,屈光不正性弱視相關(guān)視皮層神經(jīng)元活動水平及激活范圍均較屈光參差性弱視有所增加,主要集中在額葉(BA6/BA9/BA10區(qū))、頂葉后部(BA40/BA7區(qū))。 結(jié)論 1、立體視覺的形成涉及多個腦區(qū),主要位于枕葉,尤以BA17區(qū)、BA18區(qū)、BA19區(qū)為著； 2、隨弱視時間的延長,弱視患者立體視皮層活動強度及范圍增強； 3、屈光參差性弱視與屈光不正性弱視立體視較易受到損害。
[Abstract]:Objective to study the functional characteristics of stereopsis cortex in children with refractive amblyopia by using functional magnetic resonance (Blood oxygen level dependent-function magnetic resonance imaging, BOLD-fMRI) technique of blood oxygen level dependent. To compare the difference and characteristics of cerebral cortex activation between ametropia amblyopia and anisometropia amblyopia. Methods 11 cases of amblyopia were diagnosed, including 5 cases of ametropia (2 males, 3 females, mean 8 鹵1.5 years) and 6 cases of anisometropia (4 males, 2 females, mean 9 鹵2 years). All subjects were hyperopic amblyopia, central foveal fixation, right handedness. All subjects had no special history of local and systemic diseases. Full correction of ametropia before trial; fMRI. reexamination at 1 and 4 weeks after standardized amblyopia training The task program of visual stimulation was compiled by E-Prime2.0 software. The stimulation mode was red and blue stereoscopic images with contrast of nearly 80%. BOLD-fMRI data of amblyopic children were collected by SIEMENS MAGNETOM Verio3.0T magnetic resonance scanning system. The image is processed and analyzed by SPM8 software package. Comparison 1. The activation of cerebral cortex in amblyopic children at different stages was different. The changes of the activation intensity and range of visual cortex between ametropia amblyopia group and anisometropia amblyopia group at different periods. Result 1. When P value was 0.001 and the threshold of activation was 10 individual elements, the excitatory area of the eyes of the children with refractive amblyopia was occipital cortex, and the activation degree of the cortex in the BA18/19/17 area was the most significant. The range and intensity of stereoscopic visual cortex activity in amblyopia group were increased. 2. 2. When the P value was 0.05 and the threshold of activation range was 10 individual elements, the activity level and activation range of anisometropic amblyopia related neurons were increased compared with that of anisometropia amblyopia. Mainly concentrated in frontal lobe (BA6/BA9/BA10 area), posterior parietal lobe (BA40/BA7 area). Conclusion (1) the formation of stereoscopic vision involves many brain regions, mainly located in the occipital lobe, especially in the BA17, BA18 and BA19 areas, 2, with the prolongation of amblyopia time, the intensity and range of stereoscopic cortex activity in amblyopic patients are enhanced. 3, anisometropia amblyopia and ametropia amblyopia stereopsis are more easily damaged.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R777.44

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