甲狀腺相關(guān)眼病眼眶炎癥與眼表功能關(guān)系探討
發(fā)布時(shí)間：2018-10-18 21:07
【摘要】：目的研究甲狀腺相關(guān)眼病(TAO)患者眼眶炎癥水平與眼表功能間相互關(guān)系。方法采用橫斷面病例觀察研究。根據(jù)改良臨床活動(dòng)性評(píng)分將56例TAO患者分為活動(dòng)期TAO組19例與靜止期TAO組37例,并選取無(wú)眼表癥狀正常人20例作為對(duì)照組。采用OSDI問(wèn)卷定量評(píng)估眼表癥狀,測(cè)量眼表解剖參數(shù)(眼球突出度、瞼裂高度、眼瞼閉合不全程度)、淚膜破裂時(shí)間(TBUT)、角膜熒光素染色(Fl)評(píng)分、基礎(chǔ)淚液分泌試驗(yàn)(St)。對(duì)其中39例TAO患者行結(jié)膜印跡細(xì)胞學(xué)(IC)光鏡檢查并分級(jí)。3組間比較采用單因素方差分析及LSD-t檢驗(yàn),IC檢查結(jié)果比較采用χ~2檢驗(yàn)。結(jié)果活動(dòng)期TAO組與靜止期TAO組眼球突出度、瞼裂高度、眼瞼閉合不全程度比較,差別無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)�；顒�(dòng)期TAO組與靜止期TAO組TBUT均較對(duì)照組縮短(P0.001),Fl評(píng)分增高(P0.001),St減少(P0.001)�；顒�(dòng)期TAO組較靜止期TAO組OSDI評(píng)分增高(P0.01),TBUT縮短(P0.001)。IC檢查Nelson分級(jí)發(fā)現(xiàn),活動(dòng)期TAO組2~3級(jí)比例較靜止期TAO組增高(P0.001)。結(jié)論TAO患者眼眶炎癥可導(dǎo)致淚膜穩(wěn)定性下降,眼表上皮鱗狀化生。
[Abstract]:Objective to study the relationship between orbital inflammation and ocular surface function in patients with thyroid associated ophthalmopathy (TAO). Methods A cross-sectional case study was carried out. According to the modified clinical activity score, 56 patients with TAO were divided into active TAO group (n = 19) and static TAO group (n = 37). OSDI questionnaire was used to quantitatively evaluate ocular surface symptoms, surface anatomical parameters (exophthalmos, height of eyelid fissure, degree of eyelid incompetence), (Fl) score of (TBUT), corneal fluorescein staining for lacrimal film rupture time, and (St). For basic tear secretion test were measured. Among them, 39 cases of TAO were examined by conjunctival blotting cytology (IC) light microscope and graded. The results of three groups were compared by univariate ANOVA and LSD-t test, and the results of IC were compared by 蠂 ~ 2 test. Results there was no significant difference in the degree of exophthalmos, the height of eyelid fissure and the degree of eyelid incompetence between the active TAO group and the rest TAO group (P0.05). TBUT in active TAO group and quiescent TAO group was shorter than that in control group (P0.001), Fl score increased (P0.001), St decreased P0.001). The OSDI score of active TAO group was higher than that of quiescent TAO group (P0. 01), TBUT shortened (P0. 001). IC examination Nelson grade). The ratio of 2 to 3 grade in active TAO group was higher than that in quiescent TAO group (P0. 001). Conclusion Orbital inflammation in TAO patients can lead to the decrease of tear film stability and squamous metaplasia of ocular surface epithelium.
【作者單位】： 福建省立醫(yī)院眼科;福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院眼科;
【基金】：福建省衛(wèi)生和計(jì)劃生育委員會(huì)青年科研基金(2015-1-10)
【分類號(hào)】：R581;R771.3
本文編號(hào)：2280367
[Abstract]:Objective to study the relationship between orbital inflammation and ocular surface function in patients with thyroid associated ophthalmopathy (TAO). Methods A cross-sectional case study was carried out. According to the modified clinical activity score, 56 patients with TAO were divided into active TAO group (n = 19) and static TAO group (n = 37). OSDI questionnaire was used to quantitatively evaluate ocular surface symptoms, surface anatomical parameters (exophthalmos, height of eyelid fissure, degree of eyelid incompetence), (Fl) score of (TBUT), corneal fluorescein staining for lacrimal film rupture time, and (St). For basic tear secretion test were measured. Among them, 39 cases of TAO were examined by conjunctival blotting cytology (IC) light microscope and graded. The results of three groups were compared by univariate ANOVA and LSD-t test, and the results of IC were compared by 蠂 ~ 2 test. Results there was no significant difference in the degree of exophthalmos, the height of eyelid fissure and the degree of eyelid incompetence between the active TAO group and the rest TAO group (P0.05). TBUT in active TAO group and quiescent TAO group was shorter than that in control group (P0.001), Fl score increased (P0.001), St decreased P0.001). The OSDI score of active TAO group was higher than that of quiescent TAO group (P0. 01), TBUT shortened (P0. 001). IC examination Nelson grade). The ratio of 2 to 3 grade in active TAO group was higher than that in quiescent TAO group (P0. 001). Conclusion Orbital inflammation in TAO patients can lead to the decrease of tear film stability and squamous metaplasia of ocular surface epithelium.
【作者單位】： 福建省立醫(yī)院眼科;福建醫(yī)科大學(xué)附屬協(xié)和醫(yī)院眼科;
【基金】：福建省衛(wèi)生和計(jì)劃生育委員會(huì)青年科研基金(2015-1-10)
【分類號(hào)】：R581;R771.3
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1 陳良盛;;中藥治愈眼眶炎癥性包塊一例[J];福建中醫(yī)藥;1984年02期
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