【摘要】：目的觀察中重度阻塞性睡眠呼吸暫停綜合征(OSAS)患者糖化血紅蛋白(HbA1c)水平的變化,評估持續(xù)氣道正壓通氣(CPAP)治療對中重度OSAS患者HbA1c水平的影響。方法連續(xù)納入2013年1月至2015年10月診治的中重度OSAS患者330例。根據HbA1c水平將患者分為:6.0%(A組,n=116)、6.0%~6.5%(B組,n=110)和≥6.5%(C組,n=104)3組。所有患者行CPAP治療3個月。治療前后均行過夜多導睡眠監(jiān)測和HbA1c檢測。結果與A組比較,B組和C組的空腹血糖水平較高(P0.05),但B組與C組間的差異無統(tǒng)計學意義(P0.05)。CPAP治療3個月后,C組HbA1c水平和血氧飽和度(SpO_2)≤90%時間占總睡眠時間百分比(T_(SpO_2)90%)明顯低于治療前(P0.05)。Pearson相關分析顯示,年齡(r=0.44)、收縮壓(r=0.57)、舒張壓(r=0.50)、空腹血糖(r=0.64)、呼吸暫停低通氣指數(shù)(AHI)(r=0.68)、平均SpO_2(r=-0.53)、最低SpO_2(r=-0.28)、T_(SpO_2)90%(r=0.35)與HbA1c水平相關(均P0.05)。多元線性回歸分析顯示,平均SpO_2(β=-0.907)和AHI(β=0.460)是HbA1c的影響因素(均P0.05)。結論中重度OSAS患者HbA1c水平與低氧血癥嚴重程度相關。CPAP治療3個月后,HbA1c≥6.5%的中重度OSAS患者有所改善。
[Abstract]:Objective to observe the changes of glycosylated hemoglobin (HbA1c) in patients with moderate and severe obstructive sleep apnea syndrome (OSAS) and to evaluate the effect of continuous positive airway pressure (CPAP) on HbA1c level in patients with moderate and severe OSAS. Methods from January 2013 to October 2015, 330 patients with moderate and severe OSAS were included. According to the level of HbA1c, the patients were divided into three groups: 6. 0% (group A) and 6. 5% (group B) and 鈮，

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